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2732-28-7

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2732-28-7 Usage

General Description

1-(2-Methylpyridin-4-yl)ethanone is a chemical compound with the molecular formula C8H9NO. It is an organic compound with a pyridine ring substituted with a methyl group at the 2-position and a ketone group at the 1-position. 1-(2-METHYLPYRIDIN-4-YL)ETHANONE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other organic chemicals. The compound may have potential applications in the field of medicinal chemistry and drug development due to its unique structure and reactivity. However, it is important to handle and use this chemical with care, following proper safety precautions and guidelines.

Check Digit Verification of cas no

The CAS Registry Mumber 2732-28-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,3 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2732-28:
(6*2)+(5*7)+(4*3)+(3*2)+(2*2)+(1*8)=77
77 % 10 = 7
So 2732-28-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO/c1-6-5-8(7(2)10)3-4-9-6/h3-5H,1-2H3

2732-28-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-METHYLPYRIDIN-4-YL)ETHANONE

1.2 Other means of identification

Product number -
Other names 4-Acetyl-2-methyl-pyridin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2732-28-7 SDS

2732-28-7Synthetic route

4-(1-ethoxyvinyl)-2-methylpyridine

4-(1-ethoxyvinyl)-2-methylpyridine

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
With hydrogenchloride; water at 20℃; for 3h;82%
N-methoxy-N,2-dimethylisonicotinamide
1211580-90-3

N-methoxy-N,2-dimethylisonicotinamide

methyllithium
917-54-4

methyllithium

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
In tetrahydrofuran at -78 - 20℃; for 1h; Inert atmosphere;56.4%
In tetrahydrofuran at -78 - 20℃; for 1h; Inert atmosphere;56.4%
Stage #1: N-methoxy-N,2-dimethylisonicotinamide; methyllithium In tetrahydrofuran at -78 - 20℃; for 1.5h; Inert atmosphere;
Stage #2: With ammonium chloride In tetrahydrofuran
51%
In tetrahydrofuran at -78 - 20℃; for 1.5h; Inert atmosphere;51%
4-bromo-2-methylpyridine
22282-99-1

4-bromo-2-methylpyridine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In toluene at 80℃; Inert atmosphere;44%
2-methyl-4-cyanopyridine
2214-53-1

2-methyl-4-cyanopyridine

methylmagnesium bromide
75-16-1

methylmagnesium bromide

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
In tetrahydrofuran; hexane at 0℃; Grignard reaction; Reflux;25%
Stage #1: 2-methyl-4-cyanopyridine; methylmagnesium bromide In tetrahydrofuran; hexane at 0℃; Heating; Reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃;
25%
Stage #1: 2-methyl-4-cyanopyridine; methylmagnesium bromide In diethyl ether at 20℃; for 16h;
Stage #2: With hydrogenchloride In water
2-methyl-4-cyanopyridine
2214-53-1

2-methyl-4-cyanopyridine

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
With methylmagnesium bromide In water
Product distribution / selectivity;
2-methylisonicotinic acid
4021-11-8

2-methylisonicotinic acid

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 20 °C
2.1: tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 20 °C
2.1: tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 2 h / 20 °C
2.1: tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 12 h / 20 °C
2.1: tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
2,4-lutidine
108-47-4

2,4-lutidine

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium permanganate / water / 14 h / 80 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 2 h / 20 °C
3.1: tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: potassium permanganate / water / 14 h / 80 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 12 h / 20 °C
3.1: tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere
View Scheme
2-methylpyridine N-oxide
931-19-1

2-methylpyridine N-oxide

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dimethyl sulfate / 16 h / 20 °C
1.2: 16 h / 20 °C
2.1: tetrahydrofuran; hexane / 0 °C / Heating; Reflux
2.2: 20 °C
View Scheme
4-bromo-2-methylpyridine
22282-99-1

4-bromo-2-methylpyridine

1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0) / toluene / 16 h / 110 °C / Inert atmosphere
2: hydrogenchloride; water / 3 h / 20 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

2-bromo-1-(2-methylpyridin-4-yl)ethan-1-one hydrobromide
1187669-34-6

2-bromo-1-(2-methylpyridin-4-yl)ethan-1-one hydrobromide

Conditions
ConditionsYield
With hydrogen bromide; bromine; acetic acid at 0 - 80℃; for 2h;96%
With hydrogen bromide; bromine; acetic acid at 0 - 20℃;80%
With hydrogen bromide; bromine; acetic acid at 0 - 20℃;80%
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

2-bromo-1-(2-methyl-4-pyridinyl)ethanone
1187785-48-3

2-bromo-1-(2-methyl-4-pyridinyl)ethanone

Conditions
ConditionsYield
With hydrogen bromide; bromine In acetic acid at 15 - 75℃;90%
With hydrogen bromide; bromine; acetic acid at 70℃; for 2h;
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

1-(2-methylpyridin-4-yl)ethanol

1-(2-methylpyridin-4-yl)ethanol

Conditions
ConditionsYield
With dimethylsulfide borane complex; (R)-(+)-2-methyl-CBS-oxazaborolidine In tetrahydrofuran; methanol at 80℃;80%
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

(4-bromo-3-fluorophenyl)hydrazine hydrochloride

(4-bromo-3-fluorophenyl)hydrazine hydrochloride

4-(1-(2-(4-bromo-3-fluorophenyl)hydrazineylidene)ethyl)-2-methylpyridine

4-(1-(2-(4-bromo-3-fluorophenyl)hydrazineylidene)ethyl)-2-methylpyridine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol at 40℃; for 4h;80%
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

1-(2-methyl-pyridin-4-yl)-ethanone oxime
80882-67-3

1-(2-methyl-pyridin-4-yl)-ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride In methanol; water at 70 - 80℃; for 4h;67%
With hydroxylamine hydrochloride In methanol; sodium hydroxide
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

Cyclopropanecarboxaldehyde
1489-69-6

Cyclopropanecarboxaldehyde

3-cyclopropyl-1-(2-methylpyridin-4-yl)prop-2-en-1-one

3-cyclopropyl-1-(2-methylpyridin-4-yl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 20℃; for 12h;29.5%
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

2-bromo-1-(2-methyl-4-pyridinyl)ethanone hydrobromide

2-bromo-1-(2-methyl-4-pyridinyl)ethanone hydrobromide

Conditions
ConditionsYield
With hydrogen bromide; bromine; acetic acid at 15 - 80℃;
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

methyl 2-(2-(2-methylisonicotinoyl)benzofuran-5-yl)acetate
1422053-20-0

methyl 2-(2-(2-methylisonicotinoyl)benzofuran-5-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen bromide; bromine; acetic acid / 0 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 2 h / 20 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

C18H17N3O2S

C18H17N3O2S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine; hydrogen bromide; acetic acid / 2 h / 70 °C
2: ethanol / 1 h / 70 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

1-(2-methylpyridin-4-yl)ethyl 4-methylbenzenesulfonate

1-(2-methylpyridin-4-yl)ethyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

methyl 2-methyl-1-(1-(2-methylpyridin-4-yl)ethyl)-1H-indole-3-carboxylate

methyl 2-methyl-1-(1-(2-methylpyridin-4-yl)ethyl)-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

methyl 2-methyl-1-(1-(2-methylpiperidin-4-yl)ethyl)-1H-indole-3-carboxylate

methyl 2-methyl-1-(1-(2-methylpiperidin-4-yl)ethyl)-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C
4.1: platinum(IV) oxide; hydrogen; acetic acid / 40 °C / 2585.81 Torr
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

methyl 1-(1-(1-(2,2-difluoroacetyl)-2-methylpiperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxylate

methyl 1-(1-(1-(2,2-difluoroacetyl)-2-methylpiperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C
4.1: platinum(IV) oxide; hydrogen; acetic acid / 40 °C / 2585.81 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

1-(1-(1-(2,2-difluoroethyl)-2-methylpiperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxylate

1-(1-(1-(2,2-difluoroethyl)-2-methylpiperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C
4.1: platinum(IV) oxide; hydrogen; acetic acid / 40 °C / 2585.81 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 80 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

1-(1-(1-(2,2-difluoroethyl)-2-methylpiperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxylic acid

1-(1-(1-(2,2-difluoroethyl)-2-methylpiperidin-4-yl)ethyl)-2-methyl-1H-indole-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C
4.1: platinum(IV) oxide; hydrogen; acetic acid / 40 °C / 2585.81 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 80 °C
7.1: sodium hydroxide / water; tetrahydrofuran; methanol / 40 h / 80 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

1-(1-(1-(2,2-difluoroethyl)-2-methylpiperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

1-(1-(1-(2,2-difluoroethyl)-2-methylpiperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: (R)-(+)-2-methyl-CBS-oxazaborolidine; dimethylsulfide borane complex / tetrahydrofuran; methanol / 80 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 80 °C
4.1: platinum(IV) oxide; hydrogen; acetic acid / 40 °C / 2585.81 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 80 °C
7.1: sodium hydroxide / water; tetrahydrofuran; methanol / 40 h / 80 °C
8.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
8.2: 20 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

2-(2-methylpyridin-4-yl)-2-oxoacetaldehyde

2-(2-methylpyridin-4-yl)-2-oxoacetaldehyde

Conditions
ConditionsYield
With hydrogen bromide; dimethyl sulfoxide In water at 55℃; for 16h;
With hydrogen bromide In dimethyl sulfoxide at 55℃; Inert atmosphere;
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

5-(2-methylpyridin-4-yl)-3-(methylthio)-1,2,4-triazine

5-(2-methylpyridin-4-yl)-3-(methylthio)-1,2,4-triazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen bromide; dimethyl sulfoxide / water / 16 h / 55 °C
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogen bromide / dimethyl sulfoxide / 55 °C / Inert atmosphere
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

5-(2-methylpyridin-4-yl)-3-(methylsulfonyl)-1,2,4-triazine

5-(2-methylpyridin-4-yl)-3-(methylsulfonyl)-1,2,4-triazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen bromide; dimethyl sulfoxide / water / 16 h / 55 °C
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogen bromide / dimethyl sulfoxide / 55 °C / Inert atmosphere
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

5-(2-methylpyridin-4-yl)-1,2,4-triazin-3-amine

5-(2-methylpyridin-4-yl)-1,2,4-triazin-3-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen bromide; dimethyl sulfoxide / water / 16 h / 55 °C
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C
4: ammonium hydroxide / 1,4-dioxane / 1 h
View Scheme
Multi-step reaction with 4 steps
1: hydrogen bromide / dimethyl sulfoxide / 55 °C / Inert atmosphere
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h
4: ammonium hydroxide / 1,4-dioxane / 1 h
View Scheme
1-(2-methylpyridin-4-yl)ethan-1-one
2732-28-7

1-(2-methylpyridin-4-yl)ethan-1-one

6-bromo-5-(2-methylpyridin-4-yl)-1,2,4-triazin-3-amine

6-bromo-5-(2-methylpyridin-4-yl)-1,2,4-triazin-3-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen bromide; dimethyl sulfoxide / water / 16 h / 55 °C
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C
4: ammonium hydroxide / 1,4-dioxane / 1 h
5: trifluoroacetic acid; N-Bromosuccinimide / acetonitrile
View Scheme
Multi-step reaction with 5 steps
1: hydrogen bromide / dimethyl sulfoxide / 55 °C / Inert atmosphere
2: sodium hydrogencarbonate / ethanol / 1 h / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h
4: ammonium hydroxide / 1,4-dioxane / 1 h
5: trifluoroacetic acid; N-Bromosuccinimide / acetonitrile / 64 h
View Scheme

2732-28-7Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE

-

, (2021/11/13)

The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

Casein kinase 1 (CK1) inhibitor for plants (by machine translation)

-

Paragraph 0053; 0104; 0109-0112; 0117, (2020/02/14)

[Problem] to provide various lead compounds PHA derivatives, and/or circadian rhythm control agent having stronger CK1 inhibitor activity. [Solution] a compound represented by formula I, or a salt thereof or a solvate thereof. (R1 The, H or C1 - 5 A straight-chain, branched or cyclic alkyl group, alkenyl group or alkynyl group, R2 The, H, halogen (F, Cl, Br or I), or a C1 - 4 The alkyl group, the ring A, 5 - 8 membered lactam ring showing; however, R1 And R2 Except H together. )[Drawing] no (by machine translation)

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

-

Paragraph 00180; 00181; 00182, (2016/09/22)

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

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