273200-57-0

Upstream product

• 86734-59-0 3-benzyloxy-2-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 66495-88-3 3-hydroxy-2-methoxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 24677-78-9 2,3-dihydroxybenzaldehyde 

Downstream Products

• 23806-64-6 2-Methoxy-3-benzyloxy-benzoesaeure 
• 74810-83-6 1-benzyloxy-2-methoxy-3-(2-nitrovinyl)benzene 

Relevant academic research and scientific papers

Syntheses and anti-inflammatory activity of natural 1,3-diarylpropenes

First syntheses of five natural 1,3-diarylpropenes (cinnamylphenols) 2-4, 7, and 8 along with synthesis of two other natural 1,3-diarylpropenes 1 and 5 and E-isomer of mucronulastyrene (6) were achieved by Friedel- Crafts alkylation as a key step. Subsequ

NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

A compound according to Formula (I): wherein R1, LA, CyA, RA, R2, R3, and R4 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions, pain, neuroinflammatory conditions, neurodegenerative conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, cardiovascular diseases, leukemia, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

Total synthesis of two natural phenanthrenes: confusarin and a regioisomer

The title compounds were synthesized by radical cyclization of the corresponding stilbenes intermediates. The latter ones arose from a Wittig reaction in a stereoselective manner (Z isomer is either the only one or the major one). Confusarin (1) was prepared in 13 steps from gallic acid. Its regioisomer (2) was obtained in five steps from syringaldehyde.

RECEPTOR ANTAGONIST

An agent for modulating the function of an RFRP receptor, characterized by containing either a compound represented by the formula (I) [wherein ring A represents an optionally substituted aromatic ring; ring B represents an optionally substituted benzene

RECEPTOR AGONISTS

The present invention provides a TGR5 receptor agonist comprising a fused ring compound represented by the formula wherein ring A is an optionally substituted aromatic ring; and ring B' is a 5- to 8-membered ring having one or more substituents or a salt

A convenient synthesis of 4-alkoxylated isoindolin-1-ones

A short synthesis of 4-alkoxylated isoindolin-1-ones based upon the S NAr reaction applied to phosphorylated 2-methoxybenzamides followed by alkaline cleavage of the phosphoryl auxiliary is reported.

Asymmetric syntheses of isochroman-4,7-diols through intramolecular cyclization of tethered lactaldehydes

Ready cyclization through silica gel chromatography of the asymmetric phenolic lactaldehyde (14) afforded the diastereomeric pair of isochroman-4,7-diols (21) and (23) in good yield, while (17), the benzylic epimer of (14), similarly yielded the isochroma