273203-62-6

Basic information

• Product Name: MYRISTYL NICOTINATE
• Synonyms: MYRISTYL NICOTINATE;3-Pyridinecarboxylic acid, tetradecyl ester
• CAS NO: 273203-62-6
• Molecular Formula: C₂₀H₃₃NO₂
• Molecular Weight: 319.48152
• Mol File: 273203-62-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 40.2-40.8 °C
• Boiling Point: 411.733 °C at 760 mmHg
• Flash Point: 202.809 °C
• Appearance: /
• Density: 0.953 g/cm³
• Vapor Pressure: 5.46E-07mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.19±0.10(Predicted)
• CAS DataBase Reference: MYRISTYL NICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: MYRISTYL NICOTINATE(273203-62-6)
• EPA Substance Registry System: MYRISTYL NICOTINATE(273203-62-6)

Safety Data

• Hazardous Substances Data: 273203-62-6(Hazardous Substances Data)

Usage

Uses

Tetradecyl Nicotinate can be combined with other drugs in the treatment of dermatological conditions.

InChI:InChI=1/C20H33NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-23-20(22)19-15-14-16-21-18-19/h14-16,18H,2-13,17H2,1H3

Upstream product

• 112-72-1 1-Tetradecanol 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 

Related news

Analysis and stability study of MYRISTYL NICOTINATE (cas 273203-62-6) in dermatological preparations by high-performance liquid chromatography07/11/2019

Myristyl nicotinate is an ester prodrug under development for delivery of nicotinic acid to skin for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy s...detailed

Relevant articles and documents

Sunfish amphiphiles: Conceptually new carriers for DNA delivery

A conceptually new class of cationic amphiphiles, Sunfish amphiphiles, designed for the delivery of genes into cells is introduced. Sunfish amphiphiles have two hydrophobic tails, connected at the 4- and the N-position to the cationic pyridinium headgroup. Two extreme morphologies visualised by backfolding and combining of both tails at one site (matching situation) or unfolding of the tails at distinct interaction sites at biological membranes will lead to considerable differences in morphological behaviour. The underlying rationale allows controlled release by using this morphological alteration of the Sunfish/helper-lipid/DNA complex (lipoplex). The often-excellent transfection efficiencies are probably related to these morphological changes. In addition, the Sunfish amphiphiles possess low toxicities, resulting in high cell survival after internalisation. The underlying rationale, design, synthesis and in vitro transfection potential are discussed in detail. Moreover, some physico-chemical characteristics of the Sunfish amphiphiles have been studied. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.