273223-07-7

Upstream product

• 258882-42-7 acetic acid 2-(4-formyl-phenoxymethyl)-2,5,7,8-tetramethyl-2H-chromen-6-yl ester 
• 273223-06-6 4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)-benzaldehyde 
• 258882-41-6 4-((E)-4,4-Dimethoxy-2-methyl-but-2-enyloxy)-benzaldehyde 
• 151018-39-2 (E/Z)-4-bromo-1,1-dimethoxy-3-methylbut-2-ene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 700-13-0 Trimethylhydroquinone 

Downstream Products

• 107187-56-4 (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione 

Relevant academic research and scientific papers

A short synthesis of troglitazone: An antidiabetic drug for treating insulin resistance

Troglitazone was obtained in 5 steps from 4-bromo-1,1-dimethoxy-3-methylbut-2-ene with an overall yield of 7.5%. The formation of the chromane ring was achieved by condensing an unsaturated acetal with trimethylhydroquinone in the presence of bis(trifluoromethylsulfonyl)imide.