107187-56-4

Basic information

• Product Name: (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione
• Synonyms: (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione
• CAS NO: 107187-56-4
• Molecular Weight: 439.532
• Mol File: 107187-56-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione(107187-56-4)
• EPA Substance Registry System: (+/-)-5-<4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)benzyl>thiazolidine-2,4-dione(107187-56-4)

Safety Data

• Hazardous Substances Data: 107187-56-4(Hazardous Substances Data)

Upstream product

• 102224-24-8 5-[4-(4,6-Dihydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]thiazolidine-2,4-dione 
• 258882-42-7 acetic acid 2-(4-formyl-phenoxymethyl)-2,5,7,8-tetramethyl-2H-chromen-6-yl ester 
• 258882-41-6 4-((E)-4,4-Dimethoxy-2-methyl-but-2-enyloxy)-benzaldehyde 
• 151018-39-2 (E/Z)-4-bromo-1,1-dimethoxy-3-methylbut-2-ene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 700-13-0 Trimethylhydroquinone 
• 273223-07-7 acetic acid 2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxymethyl]-2,5,7,8-tetramethyl-2H-chromen-6-yl ester 
• 273223-06-6 4-(6-hydroxy-2,5,7,8-tetramethyl-2H-chromen-2-ylmethoxy)-benzaldehyde 

Downstream Products

• 97322-87-7 Troglitazone 

Relevant articles and documents

A short synthesis of troglitazone: An antidiabetic drug for treating insulin resistance

Troglitazone was obtained in 5 steps from 4-bromo-1,1-dimethoxy-3-methylbut-2-ene with an overall yield of 7.5%. The formation of the chromane ring was achieved by condensing an unsaturated acetal with trimethylhydroquinone in the presence of bis(trifluoromethylsulfonyl)imide.

STUDIES ON HINDERED PHENOLS AND ANALOGUES. 4. FORMATION OF 3,9-DIOXABICYCLODECANES AND ITS APPLICATION FOR ANTIDIABETIC AGENTS

6-Acetoxy-2,5,7,8-tetramethyl-2-phenoxymethylchroman-4-ol (2) gave a couple of dehydration products, the corresponding chromene (3), and a bicyclo compound (4).The product ratios 3/4 changed with the reaction conditions and the substituent of the phenoxym