27328-34-3

Basic information

• Product Name: N-(2,2-dimethoxyethyl)phthalimide
• Synonyms: N-(2,2-dimethoxyethyl)phthalimide;2-(2,2-Dimethoxyethyl)-1H-isoindole-1,3(2H)-dione;PHTHALIMIDOACETALDEHYDE DIMETHYL ACETAL;2-(2,2-dimethoxyethyl)isoindole-1,3-dione
• CAS NO: 27328-34-3
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.23592
• EINECS: 248-412-1
• Mol File: 27328-34-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 345°Cat760mmHg
• Flash Point: 162.5°C
• Appearance: /
• Density: 1.262g/cm³
• Vapor Pressure: 6.34E-05mmHg at 25°C
• Refractive Index: 1.553
• PKA: -2.17±0.20(Predicted)
• CAS DataBase Reference: N-(2,2-dimethoxyethyl)phthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-dimethoxyethyl)phthalimide(27328-34-3)
• EPA Substance Registry System: N-(2,2-dimethoxyethyl)phthalimide(27328-34-3)

Safety Data

• Hazardous Substances Data: 27328-34-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13NO4/c1-16-10(17-2)7-13-11(14)8-5-3-4-6-9(8)12(13)15/h3-6,10H,7H2,1-2H3

Upstream product

• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 1074-82-4 potassium phtalimide 
• 3481-09-2 N-chlorophthalimide 
• 136918-14-4 phthalimide 
• 85-44-9 phthalic anhydride 
• 22483-09-6 2,2-dimethoxyethylamine 
• 87943-35-9 Acetic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-p-tolylsulfanyl-ethyl ester 

Downstream Products

• 1417526-19-2 2-((4-(2-(diethylamino)ethyl)-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4,5-dihydro-1,2,4-oxadiazol-3-yl)methyl)isoindoline-1,3-dione 
• 765913-41-5 (1R)-(+)-1-phthalimidomethyl-1,2,3,4-tetrahydroisoquinoline 
• 765913-39-1 2-[(R)-2-((S)-Toluene-4-sulfinyl)-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl]-isoindole-1,3-dione 
• 22483-09-6 2,2-dimethoxyethylamine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND USE THEREOF

Heterocyclic compounds of Formula (I) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further disclosed are methods of using one of the heterocyclic compounds for mobilizing hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation, and for treating tissue injury, cancer, inflammatory disease, and autoimmune disease.

Five-membered azole heterocyclic compound and its preparation method, pharmaceutical composition and use thereof

The present invention relates to a five-membered azole heterocycle compound represented by the following general formula (I), a preparation method of the five-membered azole heterocycle compound, a drug composition of the five-membered azole heterocycle compound, and a use of the five-membered azole heterocycle compound in preparation of drugs for prevention or treatment of TGR5-mediated diseases. The formula (I) is represented by the instruction.

4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS

The present invention provides substituted 4,5-dihydroisoxazole derivatives of formula (I), which may be therapeutically useful, more particularly NAMPT inhibitors and in which R1 R2, Y, X, "Het" and "p" have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPT) in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted 4,5-dihydroisoxazole derivatives of formula (I) or a pharmaceutically acceptable salts or stereoisomers or N-oxide thereof.