27330-35-4 Usage
Uses
Used in Pharmaceutical Synthesis:
Ethyl 3-amino-5-chloropicolinate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, Ethyl 3-amino-5-chloropicolinate is utilized as a crucial component in the creation of compounds that aid in crop protection and enhancement of agricultural yields.
Used in Medicinal Chemistry Research:
Ethyl 3-amino-5-chloropicolinate is employed as a subject of research in medicinal chemistry, where scientists explore its biological activity and evaluate its potential as a therapeutic agent for various health conditions.
Used in Organic Compound Production:
Ethyl 3-aMino-5-chloropicolinate also serves as an essential intermediate in the production of a range of organic compounds, highlighting its significance in the field of organic chemistry and chemical engineering.
Check Digit Verification of cas no
The CAS Registry Mumber 27330-35-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,3,3 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 27330-35:
(7*2)+(6*7)+(5*3)+(4*3)+(3*0)+(2*3)+(1*5)=94
94 % 10 = 4
So 27330-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2O2/c1-2-13-8(12)7-6(10)3-5(9)4-11-7/h3-4H,2,10H2,1H3
27330-35-4Relevant academic research and scientific papers
Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists
Zhou, Zhang-Lin,Navratil, James M.,Cai, Sui Xiong,Whittemore, Edward R.,Espitia, Stephen A.,Hawkinson, Jon E.,Tran, Minhtam,Woodward, Richard M.,Weber, Eckard,Keana, John F.W.
, p. 2061 - 2071 (2007/10/03)
A series of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [3H]5,7-dicholorokynurenic acid ([3H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (13i) is the most potent antagonist, having an IC50 value of 110 nM in [3H]DCKA binding and a Kb of 11 nM in the electrophysiology assay. Compound 13i is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED50 = 2.3 mg/kg, IP).
