27334-26-5Relevant academic research and scientific papers
Red fluorescence thin film based on a strong push-pull dicyanoisophorone system
Gao, Zheng,Zhang, Xu,Chen, Yi
, p. 257 - 262 (2015)
Dicyanoisophorone derivatives (1-3), which contain a strong push-pull chromophores system, have been prepared by a two-step condensation reaction, and their fluorescence in solution, polymeric thin film and pure solid state are measured. It is found that 1-3 exhibit no or weak fluorescence in both solution and pure solid state, but strong red fluorescence in polymeric thin film. Mechanism study implies that the enhanced fluorescence of 1-3 in polymeric thin film results from the restriction of intramolecular vibrational and rotational motions. In addition, it is also found that the polarity of polymeric matrix has influence over the fluorescence of dicyanoisophorone derivatives, using PMMA as polymeric matrix, a fluorescent thin film with a strong red emission is obtained.
Modulating donor of dicyanoisophorone-based fluorophores to detect human serum albumin with NIR fluorescence
Liu, Bin,Zhao, Xiongfei,Zhou, Mei,Song, Chao,Zeng, Conghui,Qin, Tianyi,Zhang, Mingyuan,Xu, Zhongyong
supporting information, (2021/12/14)
It is urgently needed to develop NIR-fluorescent probe for detection of human serum albumin (HSA) since the interference of short-wavelength-fluorescence from endogenous species in real serum and urine. However, most previous reports were located in the short-wavelength region (a series of dicyanoisophorone (DCO)-based fluorophores 1–4 with different donor groups have been designed and investigated. A systematic study of their photophysical properties has been carried out. Among these probes, 4 exhibited NIR emission with the highest fluorescence brightness and the most sensitive signal response to HSA. Further studies demonstrated that 4 could strongly bind into the DS1 pocket of HSA with a 1:1 ratio. Importantly, the method based on 4 has been proven to be capable of sensing HSA in real serum and urine samples.
Rational Design of Crystallization-Induced-Emission Probes To Detect Amorphous Protein Aggregation in Live Cells
Bai, Yulong,Dong, Xuepeng,Gao, Zhenming,Huang, Yanan,Jin, Wenhan,Liu, Xiaojing,Liu, Yu,Lyu, Haochen,Piao, Hai-Long,Shen, Di,Tang, Yuqi,Wan, Wang,Wang, Mengdie,Zeng, Lianggang
, p. 16067 - 16076 (2021/06/17)
Unlike amyloid aggregates, amorphous protein aggregates with no defined structures have been challenging to target and detect in a complex cellular milieu. In this study, we rationally designed sensors of amorphous protein aggregation from aggregation-induced-emission probes (AIEgens). Utilizing dicyanoisophorone as a model AIEgen scaffold, we first sensitized the fluorescence of AIEgens to a nonpolar and viscous environment mimicking the interior of amorphous aggregated proteins. We identified a generally applicable moiety (dimethylaminophenylene) for selective binding and fluorescence enhancement. Regulation of the electron-withdrawing groups tuned the emission wavelength while retaining selective detection. Finally, we utilized the optimized probe to systematically image aggregated proteome upon proteostasis network regulation. Overall, we present a rational approach to develop amorphous protein aggregation sensors from AIEgens with controllable sensitivity, spectral coverage, and cellular performance.
Azetidine-Containing Heterospirocycles Enhance the Performance of Fluorophores
Zhou, Junliang,Lin, Xianfeng,Ji, Xin,Xu, Shuang,Liu, Chang,Dong, Xiaochun,Zhao, Weili,Zhao, Weili
supporting information, p. 4413 - 4417 (2020/06/05)
Fluorescent dyes are extensively utilized in various fluorescence imaging techniques. However, many existing modification strategies could not balance the performance (such as brightness, photostability, water solubility, and permeability) of fluorophores. Herein we report a general strategy to enhance the performance of donor-acceptor-type fluorophores by introducing azetidine-containing heterospirocycles to the commonly used fluorophore scaffolds. Such a strategy turned out to be a general way to develop high-quality fluorophores.
Derivative using isophorone as parent and preparation method and application thereof
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Paragraph 0009; 0040-0053, (2019/02/27)
The invention discloses a derivative using isophorone as a parent. The chemical name is (E)-2 (3-(4-(dimethylamino)styryl)-5-dimethylcyclohexyl-2-ene-1-ethylene) malonitrile and the molecular formulais C21H23N3. Thermal analysis results show that the comp
Synthesis and fluorescence of dicyanoisophorone derivatives
Zhang, Xu,Chen, Yi
, p. 531 - 536 (2013/09/12)
A class of dicyanoisophorone derivatives 1-5 with electron-donating groups has been prepared by a two-step condensation reaction. Fluorescence both in solution and in pure solid state are measured. It is found that dicyanoisophorone derivatives 1-5 exhibi
