2735-15-1

Upstream product

• 1023-66-1 4-[(E)-2-(4-nitrophenyl)ethenyl]pyridine 
• 636-98-6 p-nitrobenzene iodide 
• 2510-22-7 4-pyridylacetylene 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 101676-59-9 4-(4-nitro-phenylethynyl)-pyridine-1-oxide 
• 162412-51-3 (CO)4(P(C₆H₅)3)W((4-nitrophenyl)-4'-pyridylacetylene) 
• 162412-50-2 (CO)4(P(CH₂CH₃)3)W((4-nitrophenyl)-4'-pyridylacetylene) 
• 162412-52-4 (CO)4(P(OCH₂CH₃)3)W((4-nitrophenyl)-4'-pyridylacetylene) 
• 162412-49-9 (CO)5W((4-nitrophenyl)-4'-pyridylacetylene) 
• 179804-30-9 [fac-Re(CO)3(2,2'-bipyridine)(4-nitrophenyl-4'-pyridylacetylene)][PF₆] 

Relevant academic research and scientific papers

Hydrazine Hydrate Accelerates Neocuproine–Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation

Diimine (HN═NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine–copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.

A carrier-free and recyclable protocol for the cross-coupling of terminal alkynes with arylboronic acids in H2O/TBAB

A new and recyclable protocol was developed for Pd(OAc)2-catalyzed the cross-coupling reaction of terminal alkynes with arylboronic acids using environmentally friendly H2O/TBAB as reaction medium. A series of cross-coupling products containing internal acetylenic bond can be obtained with good selectivity and yield. The Pd(OAc)2/H2O/TBAB system was stable in the Sonogashira-type cross-coupling reaction and could be used at least three cycles without considerable decrease in catalytic performance. The results suggest that the unsupported and recyclable systems can be extended to the other realm of C&C bond formation in synthetic organic chemistry.