1023-66-1

Upstream product

• 108-89-4 picoline 
• 555-16-8 4-nitrobenzaldehdye 
• 5097-93-8 trans-4-styrylpyride 
• 872-85-5 pyridine-4-carbaldehyde 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 
• 100-43-6 4-vinylpyridine 
• 586-78-7 para-nitrophenyl bromide 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 2767-70-6 (p-nitrobenzyl)triphenylphosphonium bromide 
• 636-98-6 p-nitrobenzene iodide 
• 100-52-7 benzaldehyde 

Downstream Products

• 2735-15-1 (4-nitrophenyl)-4'-pyridylacetylene 
• 101645-12-9 trans-4-pyridine 
• 6318-70-3 4-(2-[4]pyridyl-ethyl)-aniline 
• 109219-15-0 4-(4-nitrostyryl)pyridine N-oxide 
• 101625-77-8 N-[4-((E)-2-Pyridin-4-yl-vinyl)-phenyl]-oxalamic acid ethyl ester 
• 101625-78-9 Sodium; [4-((E)-2-pyridin-4-yl-vinyl)-phenylcarbamoyl]-methanoate 
• 101676-59-9 4-(4-nitro-phenylethynyl)-pyridine-1-oxide 
• 1383439-18-6 C₁₃H₁₀N₂O₂*ClHO₄ 
• 139619-05-9 trans-4-pyridine 

Relevant academic research and scientific papers

Photophysical properties of ternary RE3+ (RE = Eu, Tb, Sm) hybrids with β-diketone functionalized linkages and 4-(4-nitrostyryl) pyridine though coordination bonding

In this paper, the organic ligands TTA and TAA are grafted onto the coupling agent to achieve the organic precursors (TTA-Si, TAA-Si) as first ligand and the organic 4-(4-nitrostyryl)pyridine (Nspy) is synthesized as the second ligand. Both of them are co

[2+2] Photodimerization of Stilbazoles Promoted by Oxalic Acid in Suspension

In this study, a very simple technique to perform efficiently photodimerization of some vinylpyridines is reported. By irradiating a stirred mixture of several stilbazoles with solid oxalic acid dihydrate dispersed in a nonpolar (i.e., cyclohexane) or moderately polar (benzene, dichloromethane, dioxane) solvent, the corresponding dimeric cyclobutane adducts were obtained in high yields and excellent regio- and stereoselectivities. The strategy could also be applied successfully to oily, waxy, or even insoluble stilbazoles. Moreover, the oxalic acid loading could be lowered to substoichiometric amounts. When further optimizations were needed, our strategy was found to be highly flexible to identify other oligocarboxylic acids as alternative additives to improve, or even overturn, the regioselectivity. Oxalic acid and other oligocarboxylic acids were found to be capable of orienting more than 50 stilbazoles toward photodimerization under these conditions.

Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead molecule that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogues inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 μM) and were safe to human keratinocytes. Compound 19, with an additional isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound. This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.

ALPHA-SYNUCLEIN LIGANDS

The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).

A small-molecule chemosensor for the selective detection of 2,4,6-trinitrophenol (TNP)

A pyridine-based small-molecule receptor (L) for the specific recognition of TNP was synthesised and characterised by 1H NMR, 13C NMR and FT-IR spectra, and the optical properties were studied by UV-Vis absorption and PL spectra. The

ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

Provided herein are isoindoline compounds such as those of formula (I), pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases. Formula (I)

Rho-kinase inhibitors

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., c

Kinetics of reductive N-O bond fragmentation: The role of a conical intersection

N-alkoxyheterocycles can act as powerful one-electron acceptors in photochemical electrontransfer reactions. One-electron reduction of these species results in formation of a radical that undergoes N-O bond fragmentation to form an alkoxy radical and a neutral heterocycle. The kinetics of this N-O bond fragmentation reaction have been determined for a series of radicals with varying substituents and extents of delocalization. Rate constants varying over 7 orders of magnitude are obtained. A reaction potential energy surface is described that involves avoidance of a conical intersection. A molecular basis for the variation of the reaction rate constant with radical structure is given in terms of the relationship between the energies of the important molecular orbitals and the reaction potential energy surface. Ab initio and density functional electronic structure calculations provide support for the proposed reaction energy surface.

Troger's base molecular scaffolds in dicarboxylic acid recognition

Artificial receptors (1-5) have been designed and synthesized from simple precursors. The chain length selectivity studies of dicarboxylic acids within the cavities of new fluorescent Troger's base molecular frameworks (1- 3) have been carried out with a critical examination of their role of rigidity as well as flexibility in selective binding in comparison to receptor 5. The chiral resolution of the racemic Troger's base receptors (1 and 2) by chiral recognition with (+)- camphoric acid using hydrogen-bonding interactions has been studied.