273727-89-2 Usage
Description
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-, also known as methylnaphthidate, is a chemical compound that contains propanone and a substituted phenethylamine structure. It is a psychoactive drug and a research chemical that acts as a dopamine reuptake inhibitor.
Used in Pharmaceutical Industry:
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)is used as a psychoactive drug for its stimulant properties, producing feelings of euphoria, increased energy, and alertness.
Used in Research Industry:
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)is used as a research chemical to study its effects on the dopamine reuptake process and its potential applications in the development of new medications.
Used in Recreational Substances:
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)is used as a designer drug, often sold online as a recreational substance. However, its safety and potential long-term effects are not well understood, and it is regulated in some jurisdictions to control its production and distribution to prevent misuse and potential harm to consumers.
Check Digit Verification of cas no
The CAS Registry Mumber 273727-89-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,3,7,2 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 273727-89:
(8*2)+(7*7)+(6*3)+(5*7)+(4*2)+(3*7)+(2*8)+(1*9)=172
172 % 10 = 2
So 273727-89-2 is a valid CAS Registry Number.
273727-89-2Relevant articles and documents
Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols
Wei, Han-Xun,Lu, Dai,Sun, Vivien,Zhang, Jing,Gu, Yongli,Osenkowski, Pamela,Ye, Wenjuan,Selkoe, Dennis J.,Wolfe, Michael S.,Augelli-Szafran, Corinne E.
, p. 2133 - 2137 (2016/04/20)
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of γ-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.
SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGYS AND THEREOF
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Page/Page column 39-40, (2009/05/28)
Aspects of the invention relate to substituted aryl propylamino-oxy-analogs and uses thereof. Aspects of the invention relate to compositions that are inhibitors of γ-secretase and uses thereof for treating subjects having, or at risk of developing, Alzheimer's disease.
