273734-07-9 Usage
Enzyme inhibitor
This synthetic CB1 receptor agonist and anandamide (N-
arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-
4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki =
1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM).
ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster
ovary cells expressing the human CB1 receptor. It also increases the
binding of [35S]GTPgS to cerebellar membranes and inhibits electrically
evoked contractions of the mouse vas deferens. ACEA produces
hypothermia in mice, an effect that is inhibited by co-administration of the
CB1 receptor antagonist SR141716A.
Check Digit Verification of cas no
The CAS Registry Mumber 273734-07-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,3,7,3 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 273734-07:
(8*2)+(7*7)+(6*3)+(5*7)+(4*3)+(3*4)+(2*0)+(1*7)=149
149 % 10 = 9
So 273734-07-9 is a valid CAS Registry Number.
273734-07-9Relevant academic research and scientific papers
Parkkari, Teija,Savinainen, Juha R.,Raitio, Katri H.,Saario, Susanna M.,Matilainen, Laura,Sirvioe, Tuomas,Laitinen, Jarmo T.,Nevalainen, Tapio,Niemi, Riku,Jaervinen, Tomi
, p. 5252 - 5258 (2006)
Retroanandamide (2f) and its 10 analogues (1a-e, 2a-e) were synthesized and evaluated for the cannabinoid receptor activation by a [35S]GTPγS binding assay using rat cerebellar membranes, and Chinese hamster ovary cell membranes expressing huma
