273735-80-1Relevant academic research and scientific papers
PROCESS FOR PRODUCING IMINOQUINAZOLINONE DERIVATIVE
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Page/Page column 11, (2010/02/15)
A novel and economical process for producing an iminoquinazolinone derivative useful as a starting material or active ingredient for medicines and agricultural chemicals. An aniline derivative represented by the general formula (II) is reacted with a halogenated formic ester to obtain a phenylcarbamic ester. The phenylcarbamic ester is reacted with a halogenating agent in the presence of a free-radical initiator to obtain a halomethylphenylcarbamic ester. The halomethylphenylcarbamic ester is reacted with hydrazine to obtain an aminoquinazoline derivative. The aminoquinazoline derivative is reacted with an aldehyde to produce an iminoquinazolinone derivative represented by the general formula (I). By the process, an iminoquinazolinone derivative useful as a starting material or active ingredient for medicines and agricultural chemicals can be efficiently provided at low cost.
Perfluoroalkylated aniline compound and process for producing the same
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, (2008/06/13)
The present invention provides an aniline derivative represented by the formula (I) wherein R1 and R2 are each H, (C1-12)alkyl, (C3-8)cycloalkyl, hydroxy(C1-12)alkyl, hydroxycarbonyl (C1-12)alkyl, (C1-6)-alkoxycarbonyl(C1-6)alkyl, —COR8, wherein R8 is H, halo-(C1-12)alkyl, (C3-8)cycloalkyl or (substituted) phenyl, COOR9, wherein R9 is a halo(C1-6)alkyl group, (substituted) phenyl or (substituted) benzyl; R3, R4, R5, R6and R7 are each H, halogen, OH, nitro, halo(C1-12)alkylthio, (substituted)amino-(C1-2)alkyl, (substituted) phenyl, (substituted) benzyl, amino, —N(R10)R11 wherein R10 and R11 are each H, alkyl, cycloalkyl, (substituted) phenyl, (substituted) benzyl, —COR8 or COOR9, or (C2-27)perfluoroalkyl, etc., and a process for producing the aniline derivative. According to the process of the present invention, perfluoroalkylaniline derivatives can be obtained by using various anilines as the substrate with a high position selectivity and high yield.
