27375-61-7Relevant academic research and scientific papers
Synthesis of Tc-99m-labeled, modified RNA
Hilger, Christoph S.,Willis, Michael C.,Wolters, Mark,Pieken, Wolfgang A.
, p. 9403 - 9406 (1998)
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-conjugated RNA was achieved by coupling S-protected MAG2/
An approach to nanobioparticles - Synthesis and characterization of fulleropeptides
Bjelakovic, Mira,Todorovic, Nina,Milic, Dragana
, p. 5291 - 5300 (2012/10/29)
Two sets of new peptides incorporating fulleropyrrolidine units - Fp-GABAn-Glym-OtBu - have been designed, synthesized and completely characterized. In the first series the chain contained only GABA (γ-aminobutyric) residues, whereas in the second one glycine moieties were also inserted as well as GABA. Most of the target compounds were prepared by DCC/DMAP-assisted coupling of previously synthesized GABA-containing fulleropyrrolidinic acid and corresponding C-protected small peptides, although for two fulleropeptides [3+2] cycloadditions of azomethine ylides to C 60 were employed. All new compounds were characterized by standard spectroscopic methods. Complete assignments of peptide spin systems were achieved by extensive NMR analysis (1H, 13C, H,H-COSY, HSQC, HMBC and TOCSY). Copyright
Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B
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Page/Page column 18, (2008/06/13)
A specific binding member that binds human ED-B, wherein the specific binding member is labelled with an isotope selected from the group consisting of 76Br, 77Br, 123I, 124I, 131I and 211At
Bromelain catalyzed synthesis of peptides in organic solvent
Tai, Dar-Fu,Fu, Shu-Lin
, p. 179 - 183 (2007/10/03)
For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz-Gly-L-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-L-Asp-L-Phe-OMe) and other dipeptides were also synthesized by this method.
Synthesis and mitogenic activity of chiral lipopeptide WS1279 and its derivatives
Kurimura,Ochiai,Achiwa
, p. 1965 - 1970 (2007/10/02)
Optically active lipopeptide derivatives have been synthesized by the use of chiral glycerol derivatives. Lipopeptide WS1279 derivatives with (R)- glycerol moieties showed a higher mitogenic activity than those with the (S)- configuration. Various N-prote
COMPOUNDS OF TIN(IV) - CATALYSTS OF AMIDE FORMATION. EFFECT OF TEMPERATURE AND NATURE OF LEAVING GROUP
Oleinik, N. M.,Garkusha-Bozhko, I. P.,Usanova, I. V.
, p. 724 - 730 (2007/10/02)
The effect of substitution of the ester oxygen atom by sulfur in p-nitrophenyl acetate on its aminolysis rate with benzylamine in benzene at 25 deg C in the presence of dibutyltin dibenzoate as catalyst was studied.Such substitution leads to a decrease in the catalytic activity by approximately a half, and this is explained by the smaller capacity of the sulfur atom for the formation of hydrogen bonds.The effect of temperature on the rate of the reaction of N-benzyloxycarbonylglycine p-nitrophenyl ester with glycine tert-butyl ester in benzene in the presence of dibutyltin dibenzoate was also investigated in the range of 10 - 50 deg C.The Arrhenius equation is not fulfilled in this case.The obtained facts demonstrate the multistage character of the catalytic reaction and do not contradict our previously proposed bifunctional mechanism of catalysis by tin(IV) compounds.
PREPARATION OF ESTERS OF AMINO ACIDS AND OF PEPTIDES UNDER MILD CONDITION
Mazurov, A. A.,Antonenko, S. V.,Andronati, S. A.
, p. 208 - 210 (2007/10/02)
A new method of obtaining esters of N-protected amino acids and peptides from complexes of their sodium salts with 15-crown-5 that are soluble in organic solvents is proposed.
COMPOUNDS OF TIN(IV) - CATALYSTS OF PEPTIDE FORMATION. EFFECT OF BASICITY AND CONCENTRATION OF AMINO COMPONENT
Garkusha-Bozhko, I. P.,Oleinik, N. M.,Litvinenko, L. M.
, p. 2068 - 2077 (2007/10/02)
The effect of dibutyltin dibenzoate and the amino component in the aminolysis of N-benzyloxycarbonyl glycine p-nitrophenyl ester (substrate) by glycine tetr-butyl ester, benzylamine, and butylamine in benzene at 25 deg C was investigated.The dependence of
Aldehyde components for use in four-component condensation ("4CC") Ugi reaction peptide synthesis
Hoyng, Charles F.,Patel, Arvind D.
, p. 4795 - 4798 (2007/10/02)
The use of 9-formylfluorene as the aldehyde component in four-component condensation (4CC) fragment strategy peptide synthesis has been investigated in the synthesis of model dipeptides.
Studies on 2-Aziridinecarboxylic Acid.III. Reaction of 1-Acyl-2-aziridinecarboxylic Acid Peptide with Amines
Nakajima, Kiichiro,Tanaka, Takumi,Morita, Kaoru,Okawa, Kenji
, p. 283 - 284 (2007/10/02)
The reaction of Z-Gly-Azy-Gly-OBzl with amines was studied.With primary amines, the 1-acyl group (Z-Gly) of the aziridine peptide mainly migrated to the reactant amine with cleaving of the amide bond between glycine and aziridine, whereas aniline and diethylamine gave diaminopropionic acid derivatives via the ring opening reaction.
