7521-91-7Relevant academic research and scientific papers
CYTOTOXIC BENZODIAZEPINE DERIVATIVES
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Paragraph 0450, (2016/04/19)
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
An approach to nanobioparticles - Synthesis and characterization of fulleropeptides
Bjelakovic, Mira,Todorovic, Nina,Milic, Dragana
, p. 5291 - 5300 (2012/10/29)
Two sets of new peptides incorporating fulleropyrrolidine units - Fp-GABAn-Glym-OtBu - have been designed, synthesized and completely characterized. In the first series the chain contained only GABA (γ-aminobutyric) residues, whereas in the second one glycine moieties were also inserted as well as GABA. Most of the target compounds were prepared by DCC/DMAP-assisted coupling of previously synthesized GABA-containing fulleropyrrolidinic acid and corresponding C-protected small peptides, although for two fulleropeptides [3+2] cycloadditions of azomethine ylides to C 60 were employed. All new compounds were characterized by standard spectroscopic methods. Complete assignments of peptide spin systems were achieved by extensive NMR analysis (1H, 13C, H,H-COSY, HSQC, HMBC and TOCSY). Copyright
