27383-89-7Relevant academic research and scientific papers
Copper-catalyzed oxidative cyclization of glycine derivatives toward 2-substituted benzoxazoles
Liu, Shan,Zhu, Zhi-Qiang,Hu, Zhi-Yu,Tang, Juan,Yuan, En
, p. 1616 - 1619 (2021)
A novel and straightforward intramolecular cyclization of glycine derivatives to 2-substituted benzoxazoles through copper-catalyzed oxidative C-H/O-H cross-coupling was described. A variety of glycine derivatives involving short peptides underwent cross-dehydrogenative-coupling readily to afford diverse 2-substituted benzoxazoles. The synthetic method has the advantages of simple operation, broad substrate scope and mild reaction conditions, thus providing an alternative effective approach for benzoxazole construction.
Visible-Light-Induced Aerobic Oxidative Csp3?H Functionalization of Glycine Derivatives for 2-Substituted Benzoxazoles
Zhu, Zhi-Qiang,Liu, Shan,Hu, Zhi-Yu,Xie, Zong-Bo,Tang, Juan,Le, Zhang-Gao
supporting information, p. 2568 - 2572 (2021/03/31)
We report a simple oxidative Csp3?H functionalization reaction of glycine derivatives by visible-light photoredox catalysis. A wide range of glycine derivatives readily undergo the oxidative cyclization to afford various 2-substituted benzoxazoles. Importantly, this photocatalytic intramolecular dehydrogenative coupling reaction allows for the C?H functionalization of glycine derivatives involving short peptides under mild conditions, which may have value in preparing peptide-derived pharmacologically active molecules. (Figure presented.).
