27384-58-3

Upstream product

• 95650-55-8 C₇H₁₇NO₂ 
• 37019-50-4 2-(dimethylamino)tetrahydropyran 
• 67-56-1 methanol 
• 2508-29-4 5-hydroxypentylamine 
• 58390-10-6 (5-Hydroxy-pentyl)-trimethyl-ammonium; hydroxide 

Downstream Products

• 71-41-0 pentan-1-ol 
• 26153-88-8 N,N-dimethyl-1-pentanamine 
• 626-67-5 N-methylcyclohexylamine 
• 93736-81-3 3.4.5-Trimethoxy-benzoesaeure-<5-dimethylamino-pentylester> 
• 29823-97-0 5-N-trimethylamino-1-pentanol iodide 

Relevant academic research and scientific papers

Enhanced product selectivity in continuous N-methylation of amino alcohols over solid acid-base catalysts with supercritical methanol

The unique properties of supercritical fluids can be exploited for fine-tuning product selectivity. Under the conditions listed for the N-methylation of amino alcohols (see scheme) over solid acid-base bifunctional catalysts, the total yield and product selectivity could be improved. Enhanced product selectivity might be attributed to the milder reaction conditions possible with supercritical methanol, as well as the increased concentration of methanol on the catalyst.

EVOLUTION THERMIQUE DE N-OXYDES D'ω-DIALKYLAMINO ALCANOLS-1

The thermolysis of ω-dimethylamino-1-alkanol N-oxides affords ω-hydroxy-1-alkenes with dimethylhydroxylamine in good yields.The other basic products (amino alcohol and isoxazolidine) involve oxidation-reduction process between the tertiary amine N-oxide and dimethylhydroxylamine, followed by 1,3-dipolar cycloaddition reaction.Pyrolysis of 5-piperidino-1-pentanol N-oxide proceeds on a path similar to the N-dimethyl compounds.The elimination of an hydrogen atom of the heterocycle does not occur: the preferred planar transition state cannot be attained because of thesteric requirements of the ring.

ETUDE DES INTERACTIONS ENTRE FONCTIONS ALCOOL ET AMINE: EVOLUTION THERMIQUE D'HYDROXYDES ET DE SELS D'ω-TRIALKYLAMMONIO ALCANOLS-1

The thermolysis of ω-hydroxyalkyltrialkylammonium hydroxides (Φ=4-8) was investigated: Elimination to alkenol competes with substitution to amino alcohol; the hydroxy group can be alkylated into aliphatic ethers by an intermolecular process; the intramolecular cyclization into cyclic ethers is important only when ω=4.Substitution reaction in amino alcohols is the main pathway for the thermolysis of ω-hydroxyalkyltrimethylammonium acetates (ω=5,6) and chloride (ω=6).