27394-96-3Relevant academic research and scientific papers
Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids
Al-Huniti, Mohammed H.,Perez, Mark A.,Garr, Matthew K.,Croatt, Mitchell P.
, p. 7375 - 7379 (2018)
Conditions for the first palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids to give the desired polyenes in good yields are presented. The reactions proceed under mild conditions using either a Pd(0) or Pd(II) catalyst and tolerate a variety of aryl and aliphatic substitutions. Unique aspects of the reaction include the requirement of phosphines, water, and a polyene adjacent to the carboxylic acid.
