273940-55-9Relevant academic research and scientific papers
Free radical reactions for heterocycle synthesis. Part 3: Formation of novel spirodilactones, spirolactone-lactams, and spirolactone-thiolactones
Zhang, Wei
, p. 2523 - 2527 (2000)
Synthesis of spirodilactones is achieved by intramolecular free radical Michael addition of enol esters derivatized from tetronic acid. Synthesis of spirolactone-lactams and spirolactone-thiolactones is also covered by the scope of this new reaction. (C)
Free radical reactions for heterocycle synthesis. Part 7: 2-Bromobenzoic acids as building blocks in the construction of spirobenzolactones and spirobenzolactams
Zhang, Wei,Pugh, Georgia
, p. 4237 - 4247 (2007/10/03)
A straightforward 2-step parallel synthesis for structurally diversified spiro compounds is developed. 2-Bromobenzoic acids are used as common building blocks to couple with a series of conjugated enoles or enamines. Sequential intramolecular free radical
