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Imidazo[1,5-a]pyrimidine is a heterocyclic compound characterized by a fused imidazole and pyrimidine ring system. This bicyclic structure features a nitrogen atom at positions 1 and 3 of the imidazole ring and positions 1 and 3 of the pyrimidine ring, with the fusion occurring between the 1,5-positions. Imidazo[1,5-a]pyrimidines are of significant interest in medicinal chemistry due to their potential as therapeutic agents, particularly in the development of antiviral and anticancer drugs. The chemical properties and reactivity of imidazo[1,5-a]pyrimidines can be influenced by the presence of various substituents on the ring system, which can modulate their biological activity and pharmacological properties.

274-67-9

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274-67-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 274-67-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 274-67:
(5*2)+(4*7)+(3*4)+(2*6)+(1*7)=69
69 % 10 = 9
So 274-67-9 is a valid CAS Registry Number.

274-67-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Imidazo[1,5-a]pyrimidine

1.2 Other means of identification

Product number -
Other names Imidazo<1,5-a>pyrimidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:274-67-9 SDS

274-67-9Relevant academic research and scientific papers

Convenient synthesis of imidazo[1,5-a]pyrimidine derivatives and their unusual recyclization into 3H-imidazo[4,5-b]pyridine derivatives

Smirnova, Olga V.,Tolkunov, Andrew S.,Tolkunov, Sergei V.,Tolkunov, Valery S.

, p. 554 - 559 (2021/06/14)

[Figure not available: see fulltext.] New derivatives of imidazo[1,5-a]pyrimidine have been synthesized by cyclization of in situ generated 1H-imidazol-4(5)-amine with 1,3-diketones or malondialdehyde derivatives. Utilization of asymmetrical 1,3-diketones leads to the formation of a mixture of regioisomers. The discovered conversion of imidazo[1,5-a]pyrimidine core into 3H-imidazo[4,5-b]pyridine that takes place only under acidic conditions can be considered as a new version of Dimroth rearrangement involving cleavage of C–N bond and formation of C–C bond.

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