2740-97-8

Basic information

• Product Name: Thiourea, N-(4-chlorophenyl)-N'-methyl-
• CAS NO: 2740-97-8
• Molecular Formula: C8H9ClN2S
• Molecular Weight: 200.692
• Mol File: 2740-97-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Thiourea, N-(4-chlorophenyl)-N'-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-(4-chlorophenyl)-N'-methyl-(2740-97-8)
• EPA Substance Registry System: Thiourea, N-(4-chlorophenyl)-N'-methyl-(2740-97-8)

Safety Data

• Hazardous Substances Data: 2740-97-8(Hazardous Substances Data)

Upstream product

• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 74-89-5 methylamine 
• 106-47-8 4-chloro-aniline 
• 556-61-6 methyl thioisocyanate 

Downstream Products

• 34551-19-4 6-chloro-N-methylbenzo[d]thiazol-2-amine 
• 174212-69-2 C₁₀H₉ClN₂OS 
• 1350612-59-7 (5Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-2-(4-chlorophenylimino)-3-methylthiazolidin-4-one 
• 57204-46-3 N,N'-bis-(4-chloro-phenyl)-2,4-dimethyl-[1,2,4]thiadiazolidine-3,5-diylidenediamine 
• 91066-64-7 (4-chloro-phenyl)-(3,4-dimethyl-3H-thiazol-2-ylidene)-amine 

Relevant articles and documents

Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions

An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.

Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS

Novel benzyl- and phenyl-isothioureidic derivatives have been synthesised and evaluated as inhibitors of nitric oxide synthesis, induced in lipopolysaccharide (LPS)-activated J774.A1 macrophage cell line. The most potent iNOS inhibitor resulting was 1-methyl-3-phenyl-S-methyl isothiourea 5l.

A facile synthesis of 2-N(methyl amino) benzothiazoles

Reaction of aromatic primary amines with methylisothiocyanate (MITC) yielded N-methyl-N1-(benzelene-1-yl)thioureas which underwent oxidative cyclization in the presence of bromine in acetic acid, at room temperature, affording the title compounds.