2741-10-8Relevant academic research and scientific papers
Base Promoted Transformation on Thiadiazolopyridinium Chlorides
Martinez, Ana,Castro, Ana,Fayet
, p. 337 - 340 (1997)
1,2,4-Thiadiazolo[2,3-a]pyridinium chlorides undergo a very facile base promoted transformation to give bispyridilimino-1,2,4-thiadiazolidines. The unequivocal structural assignment of these last compounds was achieved by spectroscopic 1H, 13C and 15N two dimensional methods.
Synthesis and antimalarial efficacy of aza-fused rhodacyanines in vitro and in the P. berghei mouse model
Takasu, Kiyosei,Pudhom, Khanitha,Kaiser, Marcel,Brun, Reto,Ihara, Masataka
, p. 4795 - 4798 (2007/10/03)
Several aza-fused rhodacyanines were synthesized and assessed for their in vitro and in vivo antimalarial activities against Plasmodium falciparum K1 and P. berghei. All synthetic compounds showed strong selective antimalarial in vitro activity. Class II azarhodacyanines, 3, consisting of four heterocyclic units, were found to display good parasitemia suppression and low acute toxicity in vivo. Among them, 3c appeared to be the most effective at a dose of 20-25 mg kg-1 day-1 (ip).
New synthetic route to 1,2,4-thiadiazolines and 1,3- thiazolines via thiadiazolopyridinium salts
Martinez, Ana,Castro, Ana,Fonseca, Isabel,Ripoll, Martin Martinez-,Cano, Felix H.,Albert, Armando
, p. 2657 - 2666 (2007/10/03)
A new efficient synthesis of 1,2,4-thiadiazolidines and 1,3- thiazolidines bearing 2-pyridylimino substituents using thiadiazolopyridinium chlorides as intermediates is described. The mechanism probably involves a base promoted nucleophilic addition of thiadiazolopyridinium salts to nitriles and ketones.
Thiadiazolopyridinium Salts: Intermediates for Heterocyclic Synthesis
Castro, Ana,Martinez, Ana
, p. 1737 - 1740 (2007/10/02)
The high reactivity of thiadiazolopyridinium salts against electrophiles is described.This fact provides a new and efficient synthetic route to several heterocycles such as thiazolines, thiadiazolines and thiadiazolin-3-ones carrying pyridyl
