27424-82-4Relevant articles and documents
Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi
Tempone, Andre Gustavo,Ferreira, Daiane Dias,Lima, Marta Lopes,Costa Silva, Thais Alves,Borborema, Samanta E.T.,Reim?o, Juliana Quero,Galuppo, Mariana K.,Guerra, Juliana Mariotti,Russell, Angelie J.,Wynne, Graham M.,Lai, Roy Y.L.,Cadelis, Melissa M.,Copp, Brent R.
, p. 947 - 960 (2017/09/08)
The neglected tropical diseases Chagas disease and leishmaniasis affect together more than 20 million people living mainly in developing countries. The mainstay of treatment is chemotherapy, however the drugs of choice, which include benznidazole and milt
Substituted 2-Pyrones, 2-Pyridones, and Other Congeners of Elasnin as Potential Agents for the Treatment of Chronic Obstructive Lung Diseases
Groutas, William C.,Stanga, Michael A.,Brubaker, Michael J.,Huang, Tien L.,Moi, Min K.,Carroll, Robert T.
, p. 1106 - 1109 (2007/10/02)
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE).The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be most inhibitors of the enzyme.These compounds are highly specific in their inhibitory