27428-63-3

Upstream product

• 643-65-2 3-methyl benzophenone 

Downstream Products

• 1356599-96-6 (E,Z)-1-(3-methylphenyl)-1-phenyl-N-(2,2,2-trifluoroethoxy)methanimine 
• 1356599-98-8 (E,Z)-1-[3-(bromomethyl)phenyl]-1-phenyl-N-(2,2,2-trifluoroethoxy)methanimine 
• 1356598-65-6 3-{4-[(3-{(E,Z)-phenyl[(2,2,2-trifluoroethoxy)imino]methyl}benzyl)amino]phenyl}propanoic acid 
• 643-65-2 3-methyl benzophenone 
• 170459-32-2 phenyl-m-tolylmethyl isocyanate 
• 55095-20-0 (RS)-(3-methylphenyl)phenylmethylamine 

Relevant academic research and scientific papers

A Deoximation Method for Deprotection of Ketones and Aldhydes Using a Graphene-Oxide-Based Co-catalysts System

The deoximation of a wide range of ketoximes and aldoximes to their corresponding carbonyl compounds with high yields has been achieved using graphene oxide (GO) and sodium nitrite (NaNO2) as highly efficient catalysts and air as the green oxidant under mild conditions. The mechanism of deprotection and recycling use of catalyst were revealed in deep experiment. The carboxylic acid groups on the GO were essential for high catalytic activity. (Figure presented.).

AGONISTS OF GPR40

The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are there-fore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.

One-step Beckmann rearrangement from carbonyl compounds and hydroxylamine hydrochloride in Al2O3/CH3SO3H (AMA) as a new reagent

A facile and efficient synthetic procedure, for one-step Beckmann rearrangement of aldehydes and ketones with hydroxylamine hydrochloride and Al2O3/CH3SO3H (AMA) has been developed; cyclohexanone has been converted into ε-caprolactam in a quantitative yield.

(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors

In the search for new ligands of the histamine H3 receptor, novel diarylalkyl carbamates (1-19 were synthesized as derivatives of 3-(1H- imidazol-4-yl)propanol and -ethanol. Carbamates were built up via isocyanates either from corresponding amines by reaction with diphosgene or from related carboxylic acid/diphenylphosphoryl azide and the alcoholic component. Sterically hindered amines were prepared in a two-step reaction sequence from corresponding ketones. Some of the title compounds showed (partial) agonist activity at the histamine H3 receptor in vitro and in vivo. Diphenylmethyl carbamate 2 was identified as a new lead structure (ED50 = 5.3 ± 2.6 mg/kg po, α = 1.0). Aromatic substitution in ortho- or para-positions of 2 led to a loss of agonist activity. meta-Substitution was tolerated to some extent. These effects seemed to be caused by steric rather than electronic properties of the substituents. An investigation of exchange of one or both phenyl rings of 2 by heterocyclic rings led to the highly active and selective thienyl derivative 18 (ED50 = 3.4 ± 1.4 mg/kg po, α = 1.0). These new (partial) agonists of the histamine H3 receptor might serve as pharmacological tools for investigating molecular aspects of the H3 receptor or as possible centrally acting therapeutic agents with oral bioavailability. (C) 2000 Elsevier Science Ltd.