55095-20-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-methylphenyl)-1-phenylmethanamine(SALTDATA: HCl) is used as a precursor or intermediate for the synthesis of various medications. Its role in the pharmaceutical industry is crucial, as it aids in the development of new drugs and the improvement of existing ones.
Used in Drug Formulation:
In the formulation of pharmaceutical drugs, 1-(3-methylphenyl)-1-phenylmethanamine(SALTDATA: HCl) is used to enhance solubility and stability. The hydrochloride salt form of the compound is particularly favored for these purposes, as it provides a more stable and easily handled alternative to the free base form.
Used in Research and Development:
1-(3-methylphenyl)-1-phenylmethanamine(SALTDATA: HCl) is also utilized in research and development settings, where it can be employed to study the properties and potential applications of phenylmethanamine class compounds. This can lead to the discovery of new uses and the development of novel pharmaceutical products.

Upstream product

• 27428-63-3 (3-methylphenyl)phenylmethanone oxime 
• 620-22-4 3-Methylbenzonitrile 
• 33497-37-9 3-methyl-α-phenylbenzenemethanimine 
• 643-65-2 3-methyl benzophenone 

Downstream Products

• 71136-00-0 (Phenyl-m-tolyl-methyl)-urea 
• 170459-32-2 phenyl-m-tolylmethyl isocyanate 
• 643-65-2 3-methyl benzophenone 

Relevant academic research and scientific papers

Hydrogen bond directed aerobic oxidation of amines via photoredox catalysis

An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors

In the search for new ligands of the histamine H3 receptor, novel diarylalkyl carbamates (1-19 were synthesized as derivatives of 3-(1H- imidazol-4-yl)propanol and -ethanol. Carbamates were built up via isocyanates either from corresponding amines by reaction with diphosgene or from related carboxylic acid/diphenylphosphoryl azide and the alcoholic component. Sterically hindered amines were prepared in a two-step reaction sequence from corresponding ketones. Some of the title compounds showed (partial) agonist activity at the histamine H3 receptor in vitro and in vivo. Diphenylmethyl carbamate 2 was identified as a new lead structure (ED50 = 5.3 ± 2.6 mg/kg po, α = 1.0). Aromatic substitution in ortho- or para-positions of 2 led to a loss of agonist activity. meta-Substitution was tolerated to some extent. These effects seemed to be caused by steric rather than electronic properties of the substituents. An investigation of exchange of one or both phenyl rings of 2 by heterocyclic rings led to the highly active and selective thienyl derivative 18 (ED50 = 3.4 ± 1.4 mg/kg po, α = 1.0). These new (partial) agonists of the histamine H3 receptor might serve as pharmacological tools for investigating molecular aspects of the H3 receptor or as possible centrally acting therapeutic agents with oral bioavailability. (C) 2000 Elsevier Science Ltd.