27429-86-3

Usage

Uses

Used in Pharmaceutical Industry:
1H-Imidazole, 2-(3-chlorophenyl)-4,5-dihydrois utilized as a precursor in the synthesis of various medications, leveraging its unique chemical structure to contribute to the development of new therapeutic agents.
Used in Organic Synthesis:
As a versatile building block, 1H-Imidazole, 2-(3-chlorophenyl)-4,5-dihydrois employed in organic synthesis to create a range of chemical compounds, expanding the scope of chemical research and product development.
Used in Antifungal Applications:
1H-Imidazole, 2-(3-chlorophenyl)-4,5-dihydrois used as an antifungal agent, capitalizing on its inherent properties to combat fungal infections, thereby contributing to the field of antimicrobial chemistry.
Used in Anti-Inflammatory Applications:
1H-Imidazole, 2-(3-chlorophenyl)-4,5-dihydrois also applied in anti-inflammatory treatments, where its properties help to reduce inflammation and associated symptoms, playing a role in the management of various inflammatory conditions.
Used in Coordination Chemistry:
1H-Imidazole, 2-(3-chlorophenyl)-4,5-dihydrofunctions as a ligand in coordination chemistry, participating in the formation of coordination compounds that have potential applications in various fields, including catalysis and materials science.

Upstream product

• 2548-79-0 3-chlorothiobenzamide 
• 107-15-3 ethylenediamine 
• 587-04-2 m-Chlorobenzaldehyde 
• 873-63-2 m-chlorobenzyl alcohol 
• 766-84-7 3-chloro-benzonitrile 

Downstream Products

• 4205-05-4 2-(4-chlorophenyl)-1H-imidazole 
• 1621586-79-5 4-(2-(3-chlorophenyl)-4,5-dihydroimidazol-1-yl)benzenesulfonamide 
• 1440421-39-5 2-(3-chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4,5-dihydro-1H-imidazole 
• 1440421-48-6 C₁₆H₁₃ClN₂O₂S 
• 1441929-51-6 C₁₄H₁₁ClN₄O₂ 
• 1441931-76-5 C₁₄H₁₃ClN₄ 
• 27423-81-0 2-(m-chlorophenyl)imidazole 

Relevant academic research and scientific papers

Synthesis of novel C-2 substituted imidazoline derivatives having the norbornene/dibenzobarrelene skeletons

Novel imidazoline derivatives were synthesized from the norbornene and dibenzobarrelene skeletons which were obtained by the Diels-Alder reactions of anthracene and cyclopentadiene with the different dienophiles, such as fumaronitrile and fumaric acid. Synthesis of the C-2 substituted imidazolines was performed with high yields from various dinitriles and diacyl dichlorides.

Isoform-selective inhibitory profile of 2-imidazoline-substituted benzene sulfonamides against a panel of human carbonic anhydrases

A series of novel benzene sulfonamides (previously evaluated as selective cyclooxygenase-2 inhibitors) has been profiled against human carbonic anhydrases I, II, IV and VII in an attempt to observe the manifestation of the well established “tail” approach

Efficient synthesis of 2-imidazolines in the presence of molecular iodine under ultrasound irradiation

An efficient one-pot synthesis process for preparing 2-imidazolines from aldehydes and ethylenediamine using molecular iodine and potassium carbonate in absolute ethanol at 25-30°C under ultrasound irradiation is described. The synthetic strategy has the following advantages: mild conditions and low costs requirements, readily available catalyst, short reaction times, simplicity of operation, and good-to-excellent yields.

Pd-catalyzed N-arylation of 2-imidazolines provides convenient access to selective cyclooxygenase-2 inhibitors

The re-emergence, in the recent years, of cyclooxygenase as a biological target in therapeutic areas other than inflammation is likely to require new optimized leads, particularly suited for the requirements of specific drug development programs. We devel

Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition

Trichloroisocyanuric acid, as a commercially available and inexpensive catalyst, was used in a new, facile and efficient procedure for the synthesis of 2-oxazolines, 2-imidazolines and 2-thiazolines through the reaction of nitriles with 2-aminoethanol, ethylenediamine or 2-aminoethanethiol under solvent-free conditions.

Efficient and one-pot catalytic synthesis of 2-imidazolines and bis-imidazolines with p-toluenesulfonic acid under solvent free conditions

A practical, efficient, and inexpensive method for the synthesis of 2-imidazoline from the reaction of nitriles with ethylenediamine or 1,2-propanediamine using p-toluenesulfonic acid or pyridinium p-toluenesulfonate under reflux conditions is reported. This catalyst can be successfully applied for the chemoselective conversion of dicyanobenzenes to corresponding mono- and bis-imidazolines. The applications of these catalysts are feasible because of easy preparation, easy handling, stability, inexpensive, good activity, and eco-friendly.

A facile and efficient synthesis of 2-imidazolines from aldehydes using hydrogen peroxide and substoichiometric sodium iodide

The reaction of aldehydes with ethylenediamine for the preparation of 2-imidazolines has been studied using hydrogen peroxide as an oxidant in the presence of sodium iodide and anhydrous magnesium sulfate. A mild, green, and efficient method is established to carry out this reaction in high yield. Georg Thieme Verlag Stuttgart · New York.

1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for the synthesis of 2-arylthiazolines and 2-arylimidazolines

A simple, facile, and efficient procedure for the synthesis of 2-arylthizolines and 2-arylimidazolines has been developed by the simple condensation of nitriles with 2-aminoethanethiol or ethylenediamine catalyzed by 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions. Selective preparation of bisthiozolines and monoimidazolines from dinitriles and also selective conversion of arylnitriles to their corresponding 2-arylthiazolines or imidazolines in the presence of alkylnitriles can be considered as considerable advantages of this method.

Mild and efficient one-pot synthesis of 2-imidazolines from nitriles using sodium hydrosulfide as catalyst

A simple and efficient method has been developed for the synthesis of 2-imidazolines through a one-pot reaction of various nitriles with ethylenediamine in the presence of sodium hydrosulfide as catalyst in high yield. Copyright Taylor & Francis Group, LLC.