27461-77-4Relevant academic research and scientific papers
PREPARATION OF N-PROTECTED α-AMINO ALCOHOLS BY ACETOXYBOROHYDRIDE REDUCTION OF N-PROTECTED α-AMINO ACID ESTERS
Soucek, Milan,Urban, Jan,Saman, David
, p. 761 - 765 (2007/10/02)
N-Protected α-amino alcohols were prepared by reduction of N-protected α-amino acid esters by sodium acetoxyborohydride in dioxane at elevated temperature.The reductions proceed with excellent yields and without racemisation.Reduction of the carbamate protecting groups was not observed.
Amino alcohols as C-Terminal Protecting Groups in Peptide Synthesis
Kashima, Choji,Harada, Kazuo,Fujioka, Yoko,Maruyama, Tatsuya,Omote, Yoshimori
, p. 535 - 540 (2007/10/02)
The synthesis of peptides using amino alcohols as C-terminal protecting groups is described.C-Terminal protection of amino acid could be accomplished by reduction of the terminal carboxyl group to a hydroxymethyl group, and regeneration of the carboxyl group could be achieved by Jones' oxidation.This method was applied to the formation of di- and tripeptides.
