27466-72-4

Upstream product

• 598-52-7 1-(methyl)-thiourea 
• 17356-08-0 thiourea 

Downstream Products

• 27422-81-7 1-ethyl-3-(5-oxo-4-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea 
• 27422-80-6 1-methyl-3-(5-oxo-4-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea 
• 27422-82-8 1-cyclohexyl-3-(5-oxo-4-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea 
• 27466-57-5 1-(5-oxo-4-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-3-propyl-urea 

Relevant academic research and scientific papers

The reaction studies of α-chloroformylarylhydrazines with thiols, thioureas and α-cyclodiketones

The reactions of α-chloroformylarylhydrazines 1 with various types of mercaptan, thiourea and α-cyclodiketone have been studied intensively. 1-Arylhydrazinecarbothioates 2 were obtained via thioesterization when α-chloroformylarylhydrazines reacted with thiols. On the other hand, compounds 3 were obtained when α-chloroformylarylhydrazines reacted with thio-containing heterocyclic compounds, which suggested a totally different mechanism in these types of reactions. Further studies on the reaction of α-chloroformylarylhydrazines 1 with thiourea compounds confirmed a novel cyclization and de-cyclization mechanism, which led to give 2-arylhydrazinecarboximidamides 5 and 1,3,4-thiadiazolin-5-ones 6. In addition, various 1,3,4-oxadiazines 9 were obtained by reacting α-chloroformylarylhydrazines with α-cyclodiketones, showing ring cyclization was involved in this type of reaction.