274676-15-2

Upstream product

• 274676-14-1 methyl (+/-)-4-methyl-2-(2-nitrophenyl)-4-pentenoate 
• 22751-23-1 (2-nitrophenyl)acetyl chloride 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 30095-98-8 methyl (2-nitrophenyl)acetate 

Downstream Products

• 274676-18-5 ethyl (E)-3-methyl-5-(2-nitrophenyl)-2-pentenoate 
• 58751-62-5 4-(2-nitrobenzene)butan-2-one 

Relevant academic research and scientific papers

Palladium(II)-catalyzed intramolecular tandem aminoalkylation via divergent C(sp3)-H functionalization

(Chemical Equation Presented) We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp3)-H functionalization, a ffording three- and five-membered-ring fused indolines in good yields under two optimized conditions, respectively. The mechanism studies have indicated that the benzylic C - H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C - H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp3)-H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles.