58751-62-5

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 274676-15-2 2-(3-methyl-3-butenyl)-1-nitrobenzene 
• 598-32-3 2-hydroxy-3-butene 
• 577-19-5 2-nitrophenyl bromide 
• 552-89-6 2-nitro-benzaldehyde 
• 115698-86-7 4-(2-nitrophenyl)but-3-en-2-one 
• 274676-14-1 methyl (+/-)-4-methyl-2-(2-nitrophenyl)-4-pentenoate 
• 30095-98-8 methyl (2-nitrophenyl)acetate 
• 7697-37-2 nitric acid 

Downstream Products

• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 
• 274676-18-5 ethyl (E)-3-methyl-5-(2-nitrophenyl)-2-pentenoate 
• 64334-96-9 2-methylquinolin-7-amine 

Relevant academic research and scientific papers

The Heck reaction of allylic alcohols catalysed by an N-heterocyclic carbene-Pd(ii) complex and toxicity of the ligand precursor for the marine benthic copepod: Amphiascoides atopus

The palladium-catalysed reaction of aryl halides and allylic alcohols is an attractive method for obtaining α,β-unsaturated aldehydes and ketones, which represent key intermediates in organic synthesis. In this context, a 1,2,3-triazol-5-ylidene (aNHC)-based palladium(ii) complex formed in situ has been found to be a selective catalyst for the syntheses of building blocks from the corresponding aryl halides and allylic alcohols, with yields ranging from 50% to 90%. The lack of toxic effects of the ligand precursor (1,2,3-triazolium salt) of the palladium(ii) complex for the harpacticoid copepod Amphiascoides atopus allowed us to contrast the efficiency of the catalytic system with the potential impact of the principal waste chemical in global aquatic ecosystems, which has not been previously addressed.

Dopamine D2 receptor selective agonist and application thereof

The invention relates to a dopamine D2 receptor selective agonist and application thereof. Specifically, the invention discloses an agonist with selectivity to DRD2 and discloses a potential application value of the agonist in disease treatment. The invention discloses an agonist with DRD2 selectivity for the first time, and the specific targeting DRD2 of the agonist can play a role in treating low dopamine related diseases such as Parkinson's disease, attention deficit hyperactivity disorder, pituitary adenoma, hyperprolactinemia, hyperactivity leg syndrome, negative schizophrenia and the like while side effects are reduced to the maximum extent.

The Heck reaction of allylic alcohols catalysed by an air-stable phosphinito complex of palladium(II)

The Heck coupling of aryl bromides with primary and secondary allylic alcohols, performed in the presence of an air-stable- phosphinito complex of palladium(II), produced the corresponding carbonyl compounds. Reactions with tertiary allylic alcohols under the same conditions generated the aromatic conjugated alcohols. Georg Thieme Verlag Stuttgart · New York.

Improving the atom efficiency of the wittig reaction by a "waste as catalyst/Co-catalyst" strategy

(Figure Presented) Waste not want not: Reported is a strategy to improve the atom economy of the Wittig reaction by using it in tandem reactions that directly employ the wastePh3PO as an in-situ-generated Lewis base catalyst/co-catalyst in the next step (see scheme).

Arenediazonium o-benzenedisulfonimides in Heck-type arylation of allylic alcohols

Arenediazonium o-benzenedisulfonimides were reacted with primary and secondary allylic alcohols. The reactions, carried out in aqueous ethanol in the presence of palladium(II) acetate as precatalyst and sodium hydrogen carbonate as base, gave the arylation products with good overall conversion. In all cases, the major products were the β-arylated carbonyl derivatives. The o-benzene-disulfonimide was recovered in high yield from all the reactions, and it was recycled for the preparation of other salts. Georg Thieme Verlag Stuttgart.