274693-49-1Relevant articles and documents
Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity
Goffin, Eric,Jacques, Nicolas,Lancellotti, Patrizio,Musumeci, Lucia,Nchimi, Alain,Pirotte, Bernard,Oury, Cécile
, (2020/09/11)
Based on the recent observation that the antiplatelet agent ticagrelor and one of its metabolite exert bactericidal activity against gram-positive bacteria, a series of 1,2,3-triazolo[4,5-d]pyrimidines structurally related to ticagrelor were synthesized and examined as putative antiplatelet and antibacterial agents. The aim was to assess the possibility of dissociating the two biological properties and to find novel 1,2,3-triazolo[4,5-d]pyrimidines expressing antiplatelet activity and devoid of in vitro antibacterial activity. The new compounds synthesized were known metabolites of ticagrelor as well as structurally simplified analogues. Some of them were found to express antiplatelet activity and to lose the antibacterial activity, supporting the view that the two activities were not necessarily linked.
Synthesis and biological evaluation of cyclopentyl-triazolol-pyrimidine (CPTP) based P2Y12 antagonists
Tu, Wangyang,Fan, Jiang,Zhang, Haitang,Xu, Guoji,Liu, Zhiwei,Qu, Jian,Yang, Fanglong,Zhang, Lei,Luan, Tianyu,Yuan, Jijun,Gong, Aishen,Feng, Jun,Sun, Piaoyang,Dong, Qing
, p. 141 - 146 (2014/01/17)
In this Letter we describe SAR investigation on the cyclopentyl-triazolol- pyrimidine scaffold in pursuit of new oral P2Y12 inhibitors. Different synthetic routes were developed for variations at the cyclopentyl core. Optimization finally led t
SYNTHESIS OF TRIAZOLOPYRIMIDINE COMPOUNDS
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Page/Page column 28, (2013/03/28)
The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of Ticagrelor (TCG).