1006376-63-1

Basic information

• Product Name: (S)-2-(3,4-Difluorophenyl)oxirane
• Synonyms: (S)-2-(3,4-Difluorophenyl)oxirane;Oxirane, 2-(3,4-difluorophenyl)-,(2S)-
• CAS NO: 1006376-63-1
• Molecular Formula: C₈H₆F₂O
• Molecular Weight: 156.1294464
• Mol File: 1006376-63-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 186.8±40.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (S)-2-(3,4-Difluorophenyl)oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(3,4-Difluorophenyl)oxirane(1006376-63-1)
• EPA Substance Registry System: (S)-2-(3,4-Difluorophenyl)oxirane(1006376-63-1)

Safety Data

• Hazardous Substances Data: 1006376-63-1(Hazardous Substances Data)

Usage

General Description

(S)-2-(3,4-Difluorophenyl)oxirane is a chemical compound with the molecular formula C8H6F2O. It is classified as an oxirane, which is a three-membered cyclic ether with one oxygen atom and two carbon atoms. (S)-2-(3,4-Difluorophenyl)oxirane is a chiral molecule, meaning it has a non-superimposable mirror image. It is commonly used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. As an epoxide, it can undergo various reactions such as ring-opening reactions to form different chemical compounds. The difluorophenyl group attached to the oxirane ring provides unique reactivity and properties, making it a valuable building block in organic chemistry. Overall, (S)-2-(3,4-Difluorophenyl)oxirane is an important chemical compound with versatile applications in the field of organic synthesis.

InChI:InChI=1/C8H6F2O/c9-6-2-1-5(3-7(6)10)8-4-11-8/h1-3,8H,4H2/t8-/m1/s1

Upstream product

• 40706-98-7 3,4-difluorophenacyl bromide 
• 369-33-5 3',4'-difluoroacetophenone 
• 405-03-8 1-(3,4-difluorophenyl)ethene 
• 111991-13-0 2-(3,4-difluorophenyl)oxirane 
• 51336-97-1 2-chloro-1-(3,4-difluorophenyl)ethanol 
• 51336-95-9 2-chloro-1-(3,4-difluorophenyl)ethan-1-one 
• 367-11-3 ortho-difluorobenzene 
• 1006376-60-8 (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 

Downstream Products

• 1006376-61-9 (1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester 
• 1402222-66-5 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride 
• 1450916-28-5 (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile 
• 1006376-62-0 (1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide 
• 1381841-55-9 (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate 
• 1381841-52-6 (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate 
• 1381841-46-8 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl isobutyl carbonate 
• 1381841-44-6 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy) thyl carbonate 
• 274693-49-1 (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 
• 220347-05-7 AR-C₁₂₄₉₁₀XX 
• 274693-27-5 ticagrelor 
• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 

Relevant articles and documents

Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity

Malaria is a prevalent and lethal disease. The fast emergence and spread of resistance to current therapies is a major concern and the development of a novel line of therapy that could overcome, the problem of drug resistance, is imperative. Screening of a set of compounds with drug/natural product-based sub-structural motifs led to the identification of spirocyclic chroman-4-one 1 with promising antimalarial activity against the chloroquine-resistant Dd2 and chloroquine-sensitive 3D7 strains of the parasite. Extensive structure-activity and structure-property relationship studies were conducted to identify the essential features necessary for its activity and properties.

Method for preparing (S)-2-(3,4-difluorophenyl)ethylene oxide

The invention relates to a method for preparing (S)-2-(3,4-difluorophenyl)ethylene oxide. The invention relates to the technical field of pharmaceutical and chemical synthesis, and discloses a methodfor producing the (S)-2-(3,4-difluorophenyl)ethylene oxi

Preparation process for (1R,2S)-1-cyano-2-(3,4-difluoro-phenyl)cyclopropane

The invention discloses a preparation process for (1R,2S)-1-cyano-2-(3,4-difluoro-phenyl)cyclopropane. The preparation process comprises the following steps: 1) in the presence of (S)-(+)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate, performing a contact reaction on 3,4-difluorostyrene and hydrogen peroxide to obtain (2S)-2-(3,4-diflurophenyl)-ethylene oxide; 2) in the presence of alkali, making the (2S)-2-(3,4-diflurophenyl)-ethylene oxide react with diethyl cyanomethylphosphonate in 1,4-dioxane to obtain a target product. By adopting the preparation process, the use of chiral raw materials is avoided, and the reaction cost is lowered; moreover, the (1R,2S)-1-cyano-2-(3,4-difluoro-phenyl)cyclopropane is synthesized conveniently through the diethyl cyanomethylphosphonate, so that high overall yield and three-dimensional selectivity are achieved; furthermore, the method is easy and convenient to operate, and is suitable for industrial expandable production.