27471-40-5

Usage

Chemical structure

Piperidone derivative with a fluorine-substituted phenyl group

Potential applications

Pharmaceutical research and drug development

Structural features

Presence of a piperidone ring and a fluorine-substituted phenyl group

Biological activities

Unknown, but may be useful in targeting various biological pathways

Further research

Required to fully understand potential uses and effects in medicine and pharmacology

Upstream product

• 675-20-7 piperidin-2-one 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 1612842-41-7 3-chloro-4-(2-fluoro-4-(1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)phenoxy)picolinamide 
• 1612842-43-9 3-chloro-4-(4-(3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamido)-2-fluorophenoxy)-picolinamide 
• 1612842-46-2 N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide 
• 1612842-49-5 N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-3-chloro-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxamide 
• 960299-43-8 1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid 
• 1612842-40-6 3-bromo-1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid 
• 1612842-39-3 isobutyl 1-(4-fluorophenyl)-2-oxopiperidine-3-carboxylate 

Relevant academic research and scientific papers

Discovery of novel c-met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold

A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indi

Discovery of novel type II c-Met inhibitors based on BMS-777607

Twenty-two new analogs based on the structure of BMS-777607 were designed, synthesized, and evaluated to determine their biological activities. Compounds bearing a cyclic sulfonamide or α-chloropiperidone scaffold exhibited good activity, which may provid