27475-19-0

Basic information

• Product Name: 3-(2-Bromo-acetyl)-benzoic acid methyl ester
• Synonyms: 3-(2-Bromo-acetyl)-benzoic acid methyl ester;Benzoic acid, 3-(broMoacetyl)-, Methyl ester;Methyl 3-(2-broMoacetyl)benzoate;Benzoic acid, 3-(2-bromoacetyl)-, methyl ester
• CAS NO: 27475-19-0
• Molecular Formula: C₁₀H₉BrO₃
• Molecular Weight: 257.08066
• Mol File: 27475-19-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 338.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.494±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2-Bromo-acetyl)-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Bromo-acetyl)-benzoic acid methyl ester(27475-19-0)
• EPA Substance Registry System: 3-(2-Bromo-acetyl)-benzoic acid methyl ester(27475-19-0)

Safety Data

• Hazardous Substances Data: 27475-19-0(Hazardous Substances Data)

Usage

General Description

3-(2-Bromo-acetyl)-benzoic acid methyl ester is a complex chemical compound. It consists of three substituents, including a bromine atom attached to a two-carbon acetyl group (2-Bromoacetyl), a benzoic acid group, and a methyl ester group. The bromine atom gives this compound a very high molecular weight, whereas the benzoic acid group imparts it with acidic properties. It also has an ester group often used in organic chemistry to increase solubility, or alter the compound’s volatility and polarity. Its applications and usage can vary greatly depending on the context and specific industry; typically it's involved in a larger synthetic chemical reaction to produce other complex compounds.

Upstream product

• 586-42-5 3-acetylbenzoic acid 
• 21860-07-1 methyl 3-acetylbenzoate 
• 62423-73-8 3-(2-bromo-acetyl)-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 79889-62-6 2-(m-methoxycarbonylphenyl)imidazo[2,1-b]benzothiazole 
• 1425037-39-3 methyl 3-(1,2,3,4-tetrahydroquinoxalin-2-yl)benzoate 
• 1259953-45-1 2-(3-methoxycarbonylphenyl)-2-oxoethyltriphenylphosphorane 
• 1600528-12-8 3-[2-(phenylthiomethyl)thiazol-4-yl]benzoic acid methyl ester 

Relevant articles and documents

Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease

We have identified potent isophthalic acid derivatives armed with imidazol and indolyl groups as potent β-secretase inhibitors. The most effective analogs demonstrated low nano-molar potency for the BACE1 (β-secretase cleaving enzyme) as measured by FRET (Fluorescence Resonance Energy Transfer) and cell-based (ELISA) assays. Our design strategy followed a traditional SAR approach and was supported by molecular modeling studies based on previously reported hydroxyethylene transition state inhibitor derived from isophthalic acid I. In the FRET assay, the most potent compound, 10a, displayed an IC50value for BACE1 of 75 nM, and exhibited cellular activity with an EC50 value of 0.81 μM. On the other hand, compound 11b was found to be the most potent compound in the cell-based assay with an EC50value of 0.29 μM.

HYDROXAMIC ACID DERIVATIVES AND HDAC8 INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds that are highly active and can highly selectively inhibit HDAC8 functionality, and HDAC8 inhibitors. SOLUTION: Each hydroxamic acid derivative comprise a compound of the general formula (1) in the figure, where φ

PYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.