27475-19-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Bromo-acetyl)-benzoic acid methyl ester is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 3-(2-Bromo-acetyl)-benzoic acid methyl ester is used as a starting material for the development of new chemical reactions and methodologies. Its reactivity and structural features make it a valuable tool for exploring novel synthetic pathways.
Used in Material Science:
3-(2-Bromo-acetyl)-benzoic acid methyl ester is employed as a building block in the synthesis of advanced materials, such as polymers and composites, with tailored properties. Its versatility in chemical reactions enables the creation of materials with improved performance in various applications.
Used in Agrochemical Industry:
3-(2-Bromo-acetyl)-benzoic acid methyl ester is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties can be exploited to develop new compounds with enhanced efficacy and selectivity in controlling pests and weeds.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 3-(2-Bromo-acetyl)-benzoic acid methyl ester is utilized as a key component in the synthesis of novel dyes and pigments. Its chemical structure contributes to the development of colors with improved stability and performance in various substrates.

Upstream product

• 21860-07-1 methyl 3-acetylbenzoate 
• 62423-73-8 3-(2-bromo-acetyl)-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 586-42-5 3-acetylbenzoic acid 

Downstream Products

• 79889-62-6 2-(m-methoxycarbonylphenyl)imidazo[2,1-b]benzothiazole 
• 802034-65-7 3-[2-(Benzyl-tert-butyl-amino)-acetyl]-benzoic acid methyl ester 
• 79889-97-7 2-(m-carboxyphenyl)imidazo<2,1-b>benzothiazole 
• 79890-33-8 3-(7-Hydroxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-benzoic acid methyl ester 
• 1350320-98-7 C₁₄H₉FN₂O₂ 
• 1259953-45-1 2-(3-methoxycarbonylphenyl)-2-oxoethyltriphenylphosphorane 

Relevant academic research and scientific papers

Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease

We have identified potent isophthalic acid derivatives armed with imidazol and indolyl groups as potent β-secretase inhibitors. The most effective analogs demonstrated low nano-molar potency for the BACE1 (β-secretase cleaving enzyme) as measured by FRET (Fluorescence Resonance Energy Transfer) and cell-based (ELISA) assays. Our design strategy followed a traditional SAR approach and was supported by molecular modeling studies based on previously reported hydroxyethylene transition state inhibitor derived from isophthalic acid I. In the FRET assay, the most potent compound, 10a, displayed an IC50value for BACE1 of 75 nM, and exhibited cellular activity with an EC50 value of 0.81 μM. On the other hand, compound 11b was found to be the most potent compound in the cell-based assay with an EC50value of 0.29 μM.

CYANOPYRROLIDINES AS DUB INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase L1 (UCHL1) and ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of cancer and conditions involving mitochondrial dysfunction. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1,R2,R3,R4,R5,R6,R7,R8 and R9 are as defined herein.

HYDROXAMIC ACID DERIVATIVES AND HDAC8 INHIBITORS

PROBLEM TO BE SOLVED: To provide compounds that are highly active and can highly selectively inhibit HDAC8 functionality, and HDAC8 inhibitors. SOLUTION: Each hydroxamic acid derivative comprise a compound of the general formula (1) in the figure, where φ

Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors

We recently discovered N-hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol- 4-yl]benzamide (NCC149) as a potent and selective histone deacetylasea 8 (HDAC8) inhibitor from a 151-member triazole compound library using a click chemistry approach. In this wor

PYRAZOLO[1,5-A]QUINAZOLIN-5(4H)-ONES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.