274925-95-0

Upstream product

• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 100-44-7 benzyl chloride 
• 6921-34-2 benzylmagnesium chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 10366-19-5 4'-hydroxy-3'-methoxy-1,2-diphenylethane 
• 274925-96-1 1-(4-benzyloxy-3-methoxyphenyl)-2-phenyl-ethanone 
• 66476-02-6 1-(4-hydroxy-3-methoxyphenyl)-2-phenylethan-1-one 
• 1026414-44-7 1-(4-hydroxy-3-methoxy-phenyl)-2-phenyl-propan-1-one 
• 709031-05-0 2-methoxy-6-nitro-4-phenethyl-phenol 
• 274925-86-9 Nebicapone 
• 1025933-64-5 1-(3,4-dihydroxy-5-nitro-phenyl)-2-phenyl-propan-1-one 
• 274925-97-2 BIA 3-270 
• 274925-88-1 1-(3,4-diacetoxy-5-nitrophenyl)-2-phenyl-ethanone 
• 1027467-20-4 1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one 
• 1027299-60-0 1-(4-benzyloxy-3-methoxy-phenyl)-2,3-diphenyl-propan-1-one 
• 1026177-82-1 (4-hydroxy-3-methoxy-5-nitro-phenyl)-(1-phenyl-cyclohexyl)-methanone 

Relevant academic research and scientific papers

Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase

A homologous series of novel nitro-catechol structures (7a-7e) were synthesized and tested as inhibitors of the enzyme catechol-O-methyltransferase (COMT). Increasing chain length was found to have significant impact on both brain penetration and duration

Improved method for demethylation of nitro-catechol methyl ethers

Several nitro-catechol compounds, useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and pyridine in ethyl acetate.