27503-81-7Relevant articles and documents
Preparation method of ultraviolet absorbent 2-phenyl benzimidazole (by machine translation)
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Paragraph 0027-0046, (2020/05/01)
The crude product 2 - obtained by the sulfonation reaction, is prepared by adding :S1: phenyl benzimidazole 2 - organic solvent, into a reaction vessel and then adding an active carbon stirring decolorizing, to fully react, to obtain ;S2:phenyl benzimidazole - 5 5-sulfonic acid crude S1 by stirring, and then adding an active carbon to remove, out of solid, after solid-liquid separation, and solid 2 - is obtained, by solid-liquid separation.S3: The product obtained by the preparation method S2 of the invention is obtained by stirring, decoloring, decoloring, decoloring and decoloring with an active carbon stirring, decolorizing layer, and then, adding an, active carbon to, prepare a crude 2 - white product (PH,) by. solid-liquid separation (step 2 -) and, solid-liquid separation, (, g,) of the product obtained, by the preparation method of, the present application, and stirring and decolorizing the crude product by stirring and decolorizing the crude product. (by machine translation)
Method for preparing sulfo-substituted benzimidazole and derivatives thereof
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Paragraph 0098-0111; 0117-0120; 0124-0127, (2019/12/25)
The invention discloses a preparation method for sulfo-substituted benzimidazole and derivatives thereof. The preparation method comprises the following steps: with organic carboxylic acid A and o-phenylenediamine as raw materials, carrying out a reflux reaction to generate a benzimidazole compound B; and reacting the benzimidazole compound B with a sulfonating agent to prepare the sulfo-substituted benzimidazole compound C. The yield and the content of the intermediate benzimidazole compound B are effectively improved by means of controlling the dosage ratio of raw materials, selecting a proper catalyst, inhibiting the oxidation of o-phenylenediamine and the like in the dehydration and cyclization process of carboxyl-amido groups; in the process of a sulfonation reaction, reaction temperature is reduced, the content and yield of the target products are obviously improved, and the generation of isomers is inhibited by controlling the addition manner of the raw materials and selecting aspecific catalyst. Meanwhile, the reaction conditions and operation of all the steps are simple, and the method is easy to control and convenient for realization of industrial production.
NEW DUALISTIC MOLECULES HAVING UV RADIATION FILTRATING ABILITY AT WIDE SPECTRUM AND POTENT DAMPING ACTIVITY OF THE REACTIVITY OF FREE RADICALS (RADICALS SCAVENGING)
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Page/Page column 35, (2013/07/19)
Compound with structure 2-phenylbenzimidazole of formula I and/or a pharmaceutically acceptable salt thereof, wherein said compound of formula I corresponds to: in which n is 1, 2 or 3 and in which R is a carboxyl radical (-COOH) or a sulphonic radical (-S03H); pharmaceutical and/or cosmetic formulation and/or medical device comprising such a compound; method for synthesising it.