2751-93-1Relevant academic research and scientific papers
The mechanism of the first step of the Mitsunobu reaction
Camp, David,Von Itzstein, Mark,Jenkins, Ian D.
, p. 4946 - 4948 (2015)
Previous DFT calculations employing phosphine (PH3) and dimethyl azodicarboxylate showed that a cyclic O,N-phosphorane was energetically favored relative to betaine formation. In this study strong experimental support for the formation of the phosphorane is described. The question of whether betaine formation occurs via nucleophilic attack of the phosphine on the azodicarboxylate as has been previously assumed, or via a [4+2] cycloaddition (cheletropic) reaction to give the O,N-phosphorane, followed by ring-opening to give the betaine has not been resolved. An answer to this intriguing question is provided.
Observation of a betaine lithium salt adduct during the course of a wittig reaction
Neumann, Robert A.,Berger, Stefan
, p. 1085 - 1087 (1998)
A stable betaine lithium salt adduct is observed during the course of a Wittig reaction. The stabilization of this adduct has been achieved by complexation with lithium ions and by using the chelating effect of pyridyl ligands. Dynamic NMR spectra are obs
