27511-35-9

Usage

Uses

Used in Chemical Synthesis:
(2S,3S)-1,4-bis[(4-methylphenyl)sulfonyl]aminobutane-2,3-diyl dimethanesulfonate is utilized as a reagent in chemical synthesis, where its specific structure allows for targeted reactions and the formation of desired products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2S,3S)-1,4-bis[(4-methylphenyl)sulfonyl]aminobutane-2,3-diyl dimethanesulfonate serves as a valuable component in research and development. Its properties make it a suitable building block for the creation of new and more complex drug molecules, potentially leading to advancements in medicinal chemistry.
Used in Organic Chemistry:
(2S,3S)-1,4-bis[(4-methylphenyl)sulfonyl]aminobutane-2,3-diyl dimethanesulfonate is also employed in the field of organic chemistry, where its sulfonyl group and unique structural features contribute to the synthesis of a variety of organic compounds.

Upstream product

• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 27511-41-7 (2R,2'R)-1,1'-di-(4-methylbenzenesulfonyl)-2,2'-biaziridine 

Relevant academic research and scientific papers

The Detosylation of Chiral 1,2-Bis(tosylamides)

The deprotection of chiral 1,2-bis(tosylamides) to their corresponding 1,2-diamines is mostly unsuccessful under standard conditions. In a new methodology, the use of Mg/MeOH with sufficient steric additions allows the facile synthesis of 1,2-diamines in 78-98% yields. These results are rationalized using density functional theory and the examination of inner and outer-sphere reduction mechanisms.

Ring-opening and -expansion of 2,2′-biaziridine: Access to diverse enantiopure linear and bicyclic vicinal diamines

The chiral pool-derived 1,1′-ditosyl-2,2′-biaziridine has been established as a valuable building block for the divergent synthesis of enantiopure vicinal diamines. Efficient procedures for the regioselective ring opening of the biaziridine with oxygen, sulfur, nitrogen, and carbon nucleophiles are described. The strategic use of nucleophiles bearing pendant functionality allows further elaboration of the acyclic products to a variety of 2,2′-bicyclic-embedded diamines. Desymmetrization of the biaziridine has also been accomplished via the selective monoaddition of organocuprates.