27522-80-1

Upstream product

• 540-23-8 p-toluidine hydrochloride 
• 100-09-4 4-methoxybenzoic acid 
• 201230-82-2 carbon monoxide 
• 540-38-5 p-Iodophenol 
• 106-49-0 p-toluidine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 27522-81-2 4-acetoxy-benzoic acid p-toluidide 

Relevant academic research and scientific papers

Cooperation of a Reductant and an Oxidant in One Pot to Synthesize Amides from Nitroarenes and Aldehydes

The reductant zinc powder and the oxidant sodium chlorate were used together in an appropriate ratio in one pot under ambient conditions, to provide an environmentally friendly, effective, and convenient method for the synthesis of aromatic amides in good yields from nitroarenes and aldehydes in the green solvents alcohol and water under atmospheric conditions. The good results indicate that reductants and oxidants with opposing properties can not only be used together without any adverse effects, but also improve the reaction yield through their cooperation.

Pd-catalyzed chemoselective carbonylation of aminophenols with iodoarenes: Alkoxycarbonylation vs aminocarbonylation

Palladium-catalyzed chemoselective carbonylation of aminophenols with iodoarenes was realized by changing ligand and base. 3- or 4-Aminophenols afforded esters in high yields and selectivities using 1,3-bis(diphenylphosphino)propane as the ligand and K2CO3 as the base, and gave amides in high yields and selectivities using 1,3-bis(diisobutylphosphino)propane as the ligand and DBU as the base. 2-Aminophenol only gave amides in high yields under both conditions.

Derivatives of p-substituted phenyl ester of pivalic acid

A derivative of general formula: STR1 wherein Y is --SO2 -- or STR2 (i) R1 and R2, which may be the same or different, each represent, (1) --H, (2) C1-16 alkyl or (3) the formula: --X-- A --(R4)n wher