27532-83-8Relevant academic research and scientific papers
Substituents effect on the erlenmeyer-ploechl reaction: Understanding an observed process reaction time
Chavez, Flavio,Kennedy, Nicole,Rawalpally, Thimma,Williamson, R. Thomas,Cleary, Thomas
experimental part, p. 579 - 584 (2011/07/08)
A systematic study on hippuric acid substituents was performed in order to better understand the influence of stereoelectronic factors on the Erlenmeyer reaction rate. In addition, two reaction systems were evaluated: Huenig's base solvent free conditions and catalytic sodium acetate in 2-methyl-THF. The effect on reaction rate of electron withdrawing and electron donating groups are reported. Specifically, the study led to the conclusion that stereoelectronic factors have significant influence in one of our key Erlenmeyer reaction by affecting its reaction rate.
Inhibitors of bacterial cystathionine β-lyase: Leads for new antimicrobial agents and probes of enzyme structure and function
Ejim, Linda J.,Blanchard, Jan E.,Koteva, Kalinka P.,Sumerfield, Rachael,Elowe, Nadine H.,Chechetto, Jonathan D.,Brown, Eric D.,Junop, Murray S.,Wright, Gerard D.
, p. 755 - 764 (2007/10/03)
The biosynthesis of methionine is an attractive antibiotic target given its importance in protein and DNA metabolism and its absence in mammals. We have performed a high-throughput screen of the methionine biosynthesis enzyme cystathionine β-lyase (CBL) a
