51579-21-6

Basic information

• Product Name: Glycine, N-(2,6-dimethoxybenzoyl)-
• CAS NO: 51579-21-6
• Molecular Formula: C11H13NO5
• Molecular Weight: 239.228
• Mol File: 51579-21-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Glycine, N-(2,6-dimethoxybenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(2,6-dimethoxybenzoyl)-(51579-21-6)
• EPA Substance Registry System: Glycine, N-(2,6-dimethoxybenzoyl)-(51579-21-6)

Safety Data

• Hazardous Substances Data: 51579-21-6(Hazardous Substances Data)

Upstream product

• 1738-68-7 Gly-OBz 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 1989-53-3 2,6-dimethoxybenzoyl chloride 
• 27532-83-8 N-(2,6-Dimethoxybenzoyl)-glycin-ethylester 
• 61-32-5 methicillin 
• 51579-20-5 methyl N-(2,6-dimethoxybenzoyl)glycine ester 

Downstream Products

• 1224962-82-6 4-(4-nitrobenzylidene)-2-(2,6-dimethoxyphenyl)-5(4H)-oxazolone 
• 1224962-97-3 4-(4-methoxybenzylidene)-2-(2,6-dimethoxyphenyl)-5(4H)-oxazolone 
• 51579-24-9 2-(2,6-dimethoxy-benzoylamino)-3,3-diethoxy-propionic acid 
• 51579-22-7 2,6-Dimethoxyphenylpenaldinsaeureethylester 
• 51703-50-5 N-[2-(2,6-dimethoxy-phenyl)-5-oxo-oxazol-4-ylidenemethyl]-penicillamine 
• 51579-27-2 N-[2-(2,6-dimethoxy-phenyl)-5-oxo-oxazol-4-ylidenemethyl]-valine 
• 51579-26-1 2-(2,6-dimethoxy-phenyl)-4-ethoxymethylene-4H-oxazol-5-one 
• 27532-83-8 N-(2,6-Dimethoxybenzoyl)-glycin-ethylester 

Relevant articles and documents

Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C

In response to the widespread use of β-lactam antibiotics bacteria have evolved drug resistance mechanisms that include the production of resistant Penicillin Binding Proteins (PBPs). Boronic acids are potent β-lactamase inhibitors and have been shown to display some specificity for soluble transpeptidases and PBPs, but their potential as inhibitors of the latter enzymes is yet to be widely explored. Recently, a (2,6-dimethoxybenzamido) methylboronic acid was identified as being a potent inhibitor of Actinomadura sp. R39 transpeptidase (IC50: 1.3 μM). In this work, we synthesized and studied the potential of a number of acylaminomethylboronic acids as inhibitors of PBPs from different classes. Several derivatives inhibited PBPs of classes A, B and C from penicillin sensitive strains. The (2-nitrobenzamido)methylboronic acid was identified as a good inhibitor of a class A PBP (PBP1b from Streptococcus pneumoniae, IC50 = 26 μM), a class B PBP (PBP2xR6 from Streptococcus pneumoniae, IC50 = 138 μM) and a class C PBP (R39 from Actinomadura sp., IC50 = 0.6 μM). This work opens new avenues towards the development of molecules that inhibit PBPs, and eventually display bactericidal effects, on distinct bacterial species.

Chemical studies of potential relevance to penicillin hypersensitivity. The synthesis of DL 2 phenoxymethylpenicillenic acid and of DL 2 (2,6 dimethoxyphenyl)penicillenic acid (I)

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