27545-73-9Relevant academic research and scientific papers
ROCK-INHIBITING COMPOUND AND USES THEREOF
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Paragraph 0089; 0090, (2020/05/07)
Disclosed herein are a compound of formula (I) and a preparation method and uses thereof. The compound shows a good inhibitory activity against ROCK, providing a new medicinal strategy to clinically treat the diseases associated with abnormal ROCK activity.
Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from β-ketothioamides
Li, Ming,Sun, Ke-Na,Wen, Li-Rong
, p. 21535 - 21539 (2016/03/08)
β-Ketothioamides (KTAs) have been used as building blocks with aldehydes and β-enaminonitriles for synthesis of 1,4-dihydropyridines in the presence of AcOH under solvent-free conditions within 5 min. This new strategy exhibits remarkable features such as high chemoselectivity, mild reaction conditions, easily available substrates, and good yields.
Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles
Ma, Miaofeng,Hou, Guohua,Wang, Junru,Zhang, Xumu
experimental part, p. 506 - 511 (2011/06/17)
The rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles was investigated by using monophosphine and bisphosphine ligands. It was found that an Rh-QuinoxP complex exhibited high enantioselectivities for β-aryl substituted β-acetylamino acrylonitriles and the Rh-JosiPhos CyPF-t-Bu complex was proven to be effective for the hydrogenation of tetrasubstituted olefins from cyclic β-acetylamino acrylonitriles.
Highly efficient RhI-catalyzed asymmetric hydrogenation of β-amino acrylonitriles
Ma, Miaofeng,Hou, Guohua,Sun, Tian,Zhang, Xiaowei,Li, Wei,Wang, Junru,Zhang, Xumu
supporting information; experimental part, p. 5301 - 5304 (2010/09/08)
(Figure Presented) It takes two to TangPhos: β-Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos = l, 1'-ditert-butyl-(2, 2')-diphospholane) catalyst system. The products, chiral β-amino nitriles, are valuable chiral building blocks for many drugs.
