27547-14-4

Upstream product

• 64723-93-9 acetaldehyde enolate 
• 62-53-3 aniline 
• 2116-65-6 4-benzyl pyridine 
• 6190-28-9 N,P,P-triphenylphosphinic amide 
• 620-08-6 4-methoxypyridine 
• 350-03-8 methyl-3-pyridylketone 
• 100-48-1 pyridine-4-carbonitrile 
• 100-54-9 pyridine-3-carbonitrile 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 110-86-1 pyridine 

Downstream Products

• 1163712-00-2 C₃H₆P^(1-) 
• 62-53-3 aniline 

Relevant academic research and scientific papers

IR absorption spectra of aniline cation, anilino radical, and phenylnitrene isolated in solid argon

Electron bombardment of aniline (PhNH2) in an Ar matrix mainly generated the aniline cation (PhNH2+), anilino (PhNH) and phenyl (Ph) radicals, and phenylnitrene (PhN). Further irradiation of the electron-bombarded matrix s

Kinetics and mechanism of the pyridinolysis of N-aryl-P,P-diphenyl phosphinic amides in dimethyl sulfoxide

Kinetic studies for the reactions of Z-N-aryl-P,P-diphenyl phosphinic amides with X-pyridines have been carried out in dimethyl sulfoxide at 85.0 °C. The two strong π-acceptor substituents, X = 4-Ac and 4-CN in the X-pyridine, exhibit positive deviations

Models for Strong Interactions in Proteins and Enzymes. 1. Enhanced Acidities of Principal Biological Hydrogen Donors

The acid dissociation energies of several key biological hydrogen donors are found to fall into a narrow range, ΔHoacid=352-355 kcal/mol.The strong acidities of these donor groups enhance the hydrogen bond strengths involved in the protein α-helix, imidazole enzyme centers and DNA.Specifically, the peptide link is modeled by the dipeptide analogue CH3CO-Ala-OCH3.Its acidity is strengthened, i.e. ΔHoacid is decreased by 8 kcal/mol compared with other amides, due to electrostatic stabilization by the second carbonyl in the peptide -CON-CH(CH3)CO- grouping.The acidity of imidazole is also strengthened by 8 kcal/mol compared with that of the parent molecule, pyrrole, primarily due to resonance stabilization of the ion.Hydrogen donor NH2 groups of adenine and cytosine are modeled by 4-aminopyrimidine, and the acidity of this amine group is strengthened by ring aza substitution.An intrinsic acidity optimized for hydrogen bonding strength therefore emerges as a common property of the diverse hydrogen donors in the protein α-helix, enzymes and DNA.This property may therefore be in part responsible for the natural selection of these molecules as principal biological hydrogen donors.

EFFETS DE CRYPTANDS ET ACTIVATION DE BASES-IV. ACTION DES HYDRURES ALCALINS SUR LES ACIDES FAIBLES. GENESE DE PHENATES, ALCOOLATES, AMIDURES ET CARBANIONS DANS LE THF ET LE BENZENE.

Metallation of a series of weak acids (phenols, alcohols, amines, and aryl methanes, pKa 7.2-33.4) by sodium and potassium hydride in presence of 2.2.1 (with NaH) et 2.2.2 (with KH) cryptands in tetrahydrofuran and benzene seems to involve activation at t