27561-62-2

Basic information

• Product Name: 1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97
• Synonyms: cyclohexyl(piperazin-1-yl)Methanone;1-(Cyclohexylcarbonyl)piperazine, [(Piperazin-1-yl)carbonyl]cyclohexane;1-(Cyclohexylcarbonyl)piperazine 97%;1-(Cyclohexylcarbonyl)piperazine≥ 97%(GC);1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97;Cyclohexyl-1-piperazinylmethanone;1-(Cyclohexylcarbonyl)piperazine, 97% white to brown solid
• CAS NO: 27561-62-2
• Molecular Formula: C₁₁H₂₀N₂O
• Molecular Weight: 196.29
• Product Categories: piperazines;API intermediates
• Mol File: 27561-62-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 84-89 °C(lit.)
• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 165.8°C
• Appearance: White to brown/Solid
• Density: 1.047g/cm³
• Vapor Pressure: 4.37E-05mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 8.47±0.10(Predicted)
• CAS DataBase Reference: 1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97(27561-62-2)
• EPA Substance Registry System: 1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97(27561-62-2)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 27561-62-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off white solid

InChI:InChI=1/C11H20N2O/c14-11(10-4-2-1-3-5-10)13-8-6-12-7-9-13/h10,12H,1-9H2

Upstream product

• 2719-27-9 cyclohexanylcarbonyl chloride 
• 98-89-5 Cyclohexanecarboxylic acid 
• 110-85-0 piperazine 

Downstream Products

• 1070772-22-3 4-[[3-[4-(cyclohexanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one 
• 1428245-56-0 C₁₈H₂₅ClN₂O₄ 
• 1594853-48-1 (4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)(cyclohexyl)methanone 
• 1154693-71-6 [4-(4-aminophenyl)-piperazin-1-yl]cyclohexylmethanone 
• 424819-33-0 C₁₇H₂₃N₃O₃ 
• 1622867-02-0 C₂₅H₂₈N₄O₃S 
• 1259917-49-1 2-(4-(cyclohexanecarbonyl)piperazin-1-yl)-N-(3,3-dimethylbutyl)acetamide 
• 1259917-85-5 2-(4-(cyclohexanecarbonyl)piperazin-1-yl)-N-(2-cyclooctylethyl)propanamide 
• 1374567-19-7 C₂₈H₃₂ClN₅O₃ 
• 1374567-75-5 C₂₀H₂₇N₅O 
• 1374567-60-8 C₂₀H₂₅N₅O₃ 

Relevant articles and documents

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.

A triazene-based new photolabile linker in solid phase chemistry

An extension of the T2 linker methodology by showing its applicability as a photocleavable linker is reported. Photocleavage was carried out with 355nm UV laser irradiation (3ω Nd-YAG) in methanol/diethyl ether and is suitable for protected amino acid derivatives, as well as simple small organic molecules including resin-bound biotin. The linker is stable under a wide range of conditions with the exception of strongly acidic media.