275818-95-6

Basic information

• Product Name: sodium difluoromethanesulfinate
• Synonyms: sodium difluoromethanesulfinate
• CAS NO: 275818-95-6
• Molecular Weight: 138.07
• Mol File: 275818-95-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: sodium difluoromethanesulfinate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium difluoromethanesulfinate(275818-95-6)
• EPA Substance Registry System: sodium difluoromethanesulfinate(275818-95-6)

Safety Data

• Hazardous Substances Data: 275818-95-6(Hazardous Substances Data)

Upstream product

• 186204-66-0 2-(difluoromethanesulfonyl)-1,3-benzothiazole 

Downstream Products

• 120067-88-1 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((difluoromethyl)thio)pyrazole-3-carbonitrile 

Relevant articles and documents

Electrochemically Promoted Fluoroalkylation-Distal Functionalization of Unactivated Alkenes

Difunctionalization of olefins represents a powerful synthetic tool and yet a challenging task. This work describes an electrochemically enabled fluoroalkylation-migration reaction of unactivated olefins in the absence of a strong oxidant or heavy metal catalyst, affording fluorinated (hetero)aryl ketones in good yields and excellent regioselectivities. The efficient and sustainable electrochemical strategy provides a rapid access to a dual functionalized fluorine-containing heterocyclic manifold.

Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides

This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides under electrochemical conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems.

Visible-Light- and Oxygen-Promoted Direct Csp2-H Radical Difluoromethylation of Coumarins and Antifungal Activities

An efficient general method using a clean and transition-metal-free photochemical strategy for the direct Csp2-H radical difluoromethylation of coumarins with HCF2SO2Na was developed. The visible-light-promoted strategy proceeds with 5 mol % Eosin Y under mild reaction conditions and showed excellent functional group compatibility. The control experiments illustrated that O2? - participated in this process and plays an important role in the reactions. Moreover, the representative products exhibited excellent antifungal activities in vitro. It was noted that the EC50 value of compound 3a was determined to be as low as 1.5463 μg/mL against Rhizoctorzia solani, which was better than Boscalid (EC50 = 2.9767 μg/mL).