27590-76-7Relevant academic research and scientific papers
Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
Jiang, Yuqi,He, Liu,Green, Jakob,Blevins, Hallie,Guo, Chunqing,Patel, Sulay Harsiddhbhai,Halquist, Matthew S.,McRae, MaryPeace,Venitz, Jürgen,Wang, Xiang-Yang,Zhang, Shijun
, p. 9718 - 9731 (2019)
NLRP3 inflammasomes have recently emerged as an attractive drug target for neurodegenerative disorders. In our continuing studies, a new chemical scaffold was designed as selective inhibitors of NLRP3 inflammasomes. Initial characterization of the lead HL
COMPOUNDS AS NLRP3 INFLAMMASOME INHIBITORS AND COMPOSITIONS AND USES THEREOF
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Page/Page column 29; 32; 41, (2021/02/12)
Scaffold compounds are used to design small molecule compounds and structure- activity relationship studies identify inhibitors of inflammation· Methods include pharmaceutical compositions of the small molecule compounds to inhibit, prevent and treat dise
