27591-01-1Relevant articles and documents
FLUORESCENCE BASED DETECTION OF SUBSTANCES
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, (2009/09/28)
A method for the fluorescent detection of a substance, the method comprising providing particles comprising a metal or a metal oxide core, wherein one or more optionally fluorescently tagged antibodies or human specific peptide nucleic acid (PNA) oligomers for binding to a substance is/are bound, directly or indirectly, to the surface of the metal or metal oxide; contacting a substrate, which may or may not have the substance on its surface, with the particles for a time sufficient to allow the antibody/PNA oligomer to bind with the substance; removing those particles which have not bound to the substrate; if the antibodies or PNA oligomers are not fluorescently tagged, contacting the substrate with one or more fluorophores that selectively bind with the antibody and/or substance, then optionally washing the substrate to remove unbound fluorophores; and illuminating the substrate with appropriate radiation to show the fluorophores on the substrate.
Naphthalenone phthalazinylhydrazones
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, (2008/06/13)
Naphthalenone phthalazinylhydrazones of the formula: STR1 are disclosed. In the above formula R1 is hydrogen or alkyl, R2 is alkyl, preferably branched alkyl, or N, R1 and R2 taken together forming a heterocyclic ring. These compounds are useful as antihypertensive agents.