2760-11-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4-dichloro-5-sulfamoylbenzamide is used as an antimicrobial agent for the treatment and prevention of bacterial infections. Its effectiveness is attributed to its ability to inhibit bacterial growth by interfering with the synthesis of essential components like folic acid, thereby disrupting the bacteria's metabolic processes.
Used in Research Laboratories:
In research settings, 2,4-dichloro-5-sulfamoylbenzamide serves as a valuable tool in studying the mechanisms of action of sulfonamide drugs and their interactions with bacterial enzymes. It aids in the development of new antimicrobial agents and the understanding of bacterial resistance to these drugs.

Upstream product

• 123-91-1 1,4-dioxane 
• 2736-23-4 2,4-dichloro-5-sulfamoylbenzoic acid 
• 3740-16-7 2,4-dichloro-5-sulphamylbenzoyl chloride 

Relevant academic research and scientific papers

Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms

By applying an approach of a “ring with two tails”, a series of novel inhibitors possessing high-affinity and significant selectivity towards selected carbonic anhydrase (CA) isoforms has been designed. The “ring” consists of 2-chloro/bromo-benzenesulfonamide, where the sulfonamide group is as an anchor coordinating the Zn(II) in the active site of CAs, and halogen atom orients the ring affecting the affinity and selectivity. First “tail” is a substituent containing carbonyl, carboxyl, hydroxyl, ether groups or hydrophilic amide linkage. The second “tail” contains aryl- or alkyl-substituents attached through a sulfanyl or sulfonyl group. Both “tails” are connected to the benzene ring and play a crucial role in selectivity. Varying the substituents, we designed compounds selective for CA VII, CA IX, CA XII, or CA XIV. Since due to binding-linked protonation reactions the binding-ready fractions of the compound and protein are much lower than one, the “intrinsic” affinities were calculated that should be used to study correlations between crystal structures and the thermodynamics of binding for rational drug design. The “intrinsic” affinities together with the intrinsic enthalpies and entropies of binding together with co-crystal structures were used demonstrate structural factors determining major contributions for compound affinity and selectivity.

Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases

Rational design of compounds that would bind specific pockets of the target proteins is a difficult task in drug design. The 12 isoforms of catalytically active human carbonic anhydrases (CAs) have highly similar active sites that make it difficult to des

Process for the manufacture of 5-sulfamoyl-anthranilic acids

A process for the manufacture of sulfamoyl anthranilic acids of the general formula I STR1 in which Ph is phenyl substituted with 1 or 2 halogen atoms, alkyl groups or etherified hydroxy groups, and R is aralkyl, heteroaralkyl or cycloalkyl-alkyl, unsatur