27602-76-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(6-methoxy-2-naphthyl)propanal oxime is used as an impurity in the production of Naproxen (N377525), an anti-inflammatory, analgesic, and antipyretic agent. Its presence, although as an impurity, is significant in the synthesis process of Naproxen, which is a widely used NSAID for treating various conditions such as pain, inflammation, and fever.
As an impurity, it is essential to monitor and control the levels of 2-(6-methoxy-2-naphthyl)propanal oxime in the final Naproxen product to ensure safety, efficacy, and quality standards are met. The pharmaceutical industry relies on stringent quality control measures to minimize the presence of impurities like this oxime compound in the final drug formulation.

Upstream product

• 27602-75-1 2-(6-methoxy-2-naphthyl)propanal 
• 27602-74-0 2-(6-methoxynaphth-2-yl)-1,2-propylene oxide 

Downstream Products

• 55577-80-5 D-6-methoxy-α-methyl-2-naphthaleneacetic acid sodium salt 
• 23981-80-8 naproxen 

Relevant academic research and scientific papers

Method for preparing naproxen intermediate

A technical scheme of the invention provides a method for preparing a naproxen intermediate represented by a chemical structural formula I. Preparation reactions are as follows: 6-methoxy-2-acetonaphthone and trimethyl sulfonium hydrogen sulfate are subjected to an epoxidation reaction in the presence of alkali so as to prepare 2-(6-methoxynaphthyl)-1,2-epoxypropane, the 2-(6-methoxynaphthyl)-1,2-epoxypropane is subjected to catalyzed rearrangement through silica gel or FeCl3 and then reacts with hydroxylamine hydrochloride, thereby preparing an intermediate, i.e., 2-(6-methoxy-2-naphthyl)propyl oxime (I) in one step. Naproxen is prepared by employing a one-pot method through a key intermediate, i.e., 2-(6-methoxy-2-naphthyl)propyl oxime.

NAPROXCINOD PROCESS AND SOLID DISPERSION

Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6-methoxy-2-naphthyl)-propanoate and methods for its preparation.