27619-89-2

Basic information

• Product Name: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
• Synonyms: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride;2-(Tridecafluorohexyl)ethanesulfonic acid chloride;3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluoro-1-octanesulfonyl chloride;1-Octanesulfonyl chloride, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-;Einecs 248-576-4;FS SA-6l;3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctanesulfonyl chloride
• CAS NO: 27619-89-2
• Molecular Formula: C₈H₄ClF₁₃O₂S
• Molecular Weight: 446.6134016
• EINECS: 248-576-4
• Mol File: 27619-89-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 24-26 °C
• Boiling Point: 237.8°Cat760mmHg
• Flash Point: 97.6°C
• Appearance: /
• Density: 1.69g/cm³
• Vapor Pressure: 0.0678mmHg at 25°C
• Refractive Index: 1.333
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetone (Slightly), DMSO (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride(27619-89-2)
• EPA Substance Registry System: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride(27619-89-2)

Safety Data

• Hazardous Substances Data: 27619-89-2(Hazardous Substances Data)

Usage

Uses

3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluoro-1-octanesulfonyl Chloride is an intermediate in synthesizing 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-sulphonic Acid (), an aliphatic compound for fluorinated surfactant synthesis.

InChI:InChI=1/C8H4ClF13O2S/c9-25(23,24)2-1-3(10,11)4(12,13)5(14,15)6(16,17)7(18,19)8(20,21)22/h1-2H2

Upstream product

• 2043-57-4 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane 
• 27619-97-2 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-sulphonic acid 
• 26650-09-9 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl thiocyanate 

Downstream Products

• 34455-22-6 N-(3-(dimethylamino)propyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-sulfonamide 

Relevant articles and documents

PREPARATION OF FLUORINE-LABELLED COMPOUNDS

The invention relates to a process for producing a fluorine-labelled compound, the process comprising: (a) treating a compound of formula (I) wherein R1, R2 and the C(H) group to which R1 and R2 are bonded together form a moiety to be labelled with fluorine; and the fluorous tag is a group of formula (II) wherein Rf is a straight-chained or branched C4-I2 perfluoroalkyl group; and L is a single bond, -alk-, -arylene-, -alk-arylene-, alk-X-, -arylene-X-, -alk-arylene-X, -alk- X-arylene-, -alk-X-arylene-X-, -arylene-alk-, -arylene-X-alk-, -arylene-alk-X- or - arylene-X-alk-X-, wherein X is N(R ), O, S, C(O) or C(O)N(R ) and wherein alk is unsubstituted or substituted C1-10 alkylene which is optionally interrupted by N(R ), O, S, C(O), C(O)N(R ) or arylene, wherein R is C1-6 alkyl or aryl; with [nF], wherein nF is 18F or 19F, thereby fluorinating and detagging the compound of formula (I) to produce a fluorine-labelled compound of formula (III) The invention further relates to compounds of formula (I), a process for producing such compounds, and a combination product which comprises the two reactants used in that process.

Mixed fluoroalkyl-alkyl surfactants

A surfactant of formula 1 [in-line-formulae](Rf-A)a-Q-([B]k—R)b??Formula 1[/in-line-formulae] wherein a and b are each independently 1 or 2;Rf is a linear or branched perfluoroalkyl radical having from 2 to about 20 carbon atoms, optionally interrupted with at least one oxygen;R is a C1 to C20 linear, branched or cyclic alkyl, or a C6 to C10 aryl;B is —(CH2CHR1O)x—,k is 0 or 1, x is 1 to about 20,A is —(CH2)m[(CHR1CH2O)]s—[(CH2)m(CH)tCHOH(CH2)m]e—, wherein each m is independently 0 to 3, s is 0 to about 30, t is 0 or 1, and e is 0 or 1,R1 is H or CH3,Q is: —OP(O)(O?M+)(O)—,—O—,—S—(CH2)m—C(O)—O—,—SO2—O——CH2CH2O—C(O)CH2C(OH)(V)CH2C(O)O—;—(CH2CH2O)xCH2CH(OH)—(CH2CH2O)x—(CH2)m—Si[OSi(R2)3]2—, —SO2NR2—,—(CH2CH2O)zC(O)CH(SO3?M+)CH2C(O)(OCH2CH2)z—wherein z is 1 to about 15, or a bond when s is a positive integer,V is —C(O)OR3 and R3 is H, CH3 or Rf;R2 is C1 to C4 alkyl, andM+ is a Group 1 metal or an ammonium (NHxR2y)+ cation wherein x+y=4, and R2 is C1 to C4 alkyl,provided that when Q is —OP(O)(O?M+)(O)— or when Q is —(CH2CH2O)z—C(O)CH(SO3?M+)CH2C(O)(OCH2CH2)z—, then at least one of s or e is a positive integer.

Pharmaceutical Compositions Based on Fluorinated Sulphamides and Sulphinimides

Pharmacuetical composition comprising compounds of formula (I): [in-line-formulae]NZ1Z2Z3 ??(I) [/in-line-formulae] in which: Z1, Z2, Z3 each independently of the others represents: a hydrogen atom; C1-C6-alkyl group; a group —SO2R3 wherein R3 represents a linear or branched C1-C12-alkyl, -alkenyl or -alkynyl group, a C3-C10-cycloalkyl group or a C6-C10-aryl group, a (C1-C6)-alkyl-(C6-C14)-aryl group, or a C5-C10-heteroaryl group; it being understood that at least one of the groups Z1, Z2, Z3 represents a group of formula (II) [in-line-formulae]X—RF—(CH2)n—SO2—??(II) [/in-line-formulae] X, RF and n being as defined in claim 1.